ArticleInfection and immunity2012
Bundle-forming pilus locus of Aeromonas veronii bv. Sobria.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Article
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- Precisely Controlling Csr sRNA Levels by MshH Enhances Vibrio cholerae Colonization in Adult Mice.Applied and environmental microbiology · 2023Article
- Genomic Characterization ofAntibiotics (Basel, Switzerland) · 2023Article
- The mobile gene cassette carrying tetracycline resistance genes inFrontiers in microbiology · 2023Article
- Whole genome sequence analysis ofFrontiers in microbiology · 2023Article
- Heterogeneous glycosylation and methylation of the Aeromonas caviae flagellin.MicrobiologyOpen · 2022Article
- Characterization of virulence and antimicrobial resistance genes ofFrontiers in microbiology · 2022Article
- Isolation of Skin Leukocytes Uncovers Phagocyte Inflammatory Responses During Induction and Resolution of Cutaneous Inflammation in Fish.Frontiers in immunology · 2021Article
- Virulence characteristics and antimicrobial resistance of Aeromonas veronii biovar sobria 312M, a clinical isolate.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- An iTRAQ-Based Comparative Proteomics Analysis of the Biofilm and Planktonic States ofInternational journal of molecular sciences · 2020Article
- Draft Whole-Genome Sequences of 10Microbiology resource announcements · 2019Article
- Comparative genomics of Aeromonas veronii: Identification of a pathotype impacting aquaculture globally.PloS one · 2019Article
- The Social Life ofFrontiers in microbiology · 2017Review
- Novel insights into the pathogenicity of epidemic Aeromonas hydrophila ST251 clones from comparative genomics.Scientific reports · 2015Article
- Arabinose induces pellicle formation by Vibrio fischeri.Applied and environmental microbiology · 2013Article
- The main Aeromonas pathogenic factors.ISRN microbiology · 2012Article
- Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the colonization mechanisms of Aeromonas spp. Previous work has suggested that the type IV bundle-forming pilus (Bfp) is an aeromonad intestinal colonization factor. This study provides the first genetic characterization of this structure. To define the role of Bfp in Aeromonas veronii bv. Sobria adherence, a 22-kb locus encoding the bundle-forming pilus was isolated; this contained 17 pilus-related genes similar to the mannose-sensitive hemagglutinin (MSHA) of Vibrio cholerae. Reverse transcriptase PCR (RT-PCR) demonstrated that the locus had two major transcriptional units, mshI to mshF and mshB to mshQ. Transcriptional fusion experiments demonstrated the presence of two strong promoters upstream of mshI and mshB. The locus encoded four putative prepilin proteins, one of which (MshA) corresponded to the N-terminal sequence of the previously isolated major pilin protein. All the pilin genes were inactivated, mutation of each minor or major pilin gene greatly reduced the bacterium's ability to adhere and form biofilms, and complementation of each mutant in trans rescued this phenotype. Mutation of the major pilin MshA and MshB, a minor pilin, resulted in their loss. The position of the mshH gene is conserved within a number of bacteria, and we have shown it is not transcriptionally linked to the other msh genes; moreover, its mutation did not have a dramatic effect on either adhesion or biofilm formation. We conclude that the bundle-forming pilus is required for A. veronii bv. Sobria adherence and biofilm formation; furthermore, both the major and minor pilin proteins are essential for this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.