ArticleHypertension (Dallas, Tex. : 1979)2012
Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure.
Article in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- New insights and predictability from in vivo recordings of paroxysmal sympathetic hyperactivity in disorders of consciousness.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Effects of high-dose alacepril on the renin-angiotensin-aldosterone system and autonomic nervous system function in healthy dogs.Veterinary research communications · 2025Article
- Influence of sex and sedentary conditions on sympathetic burst characteristics in prepubertal, postpubertal, and young adult rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Frequency-coded patterns of sympathetic vasomotor activity are differentially evoked by the paraventricular nucleus of the hypothalamus in the Goldblatt hypertension model.Frontiers in cellular neuroscience · 2023Article
- Angiotensin II and the Cardiac Parasympathetic Nervous System in Hypertension.International journal of molecular sciences · 2021Review
- Brain angiotensin converting enzyme-2 in central cardiovascular regulation.Clinical science (London, England : 1979) · 2020Review
- Renal Sensory Activity Regulates the γ-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension.Frontiers in physiology · 2020Article
- Systemic angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep.Bioscience reports · 2018Article
- Major Autonomic Neuroregulatory Pathways Underlying Short- and Long-Term Control of Cardiovascular Function.Current hypertension reports · 2016Review
- Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review).Molecular medicine reports · 2015Review
- Current Approaches to Quantifying Tonic and Reflex Autonomic Outflows Controlling Cardiovascular Function in Humans and Experimental Animals.Current hypertension reports · 2015Review
- The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction.European heart journal · 2015Review
- The role of the renal afferent and efferent nerve fibers in heart failure.Frontiers in physiology · 2015Review
- Time and technology will tell: the pathophysiologic basis of neurohormonal modulation in heart failure.Heart failure clinics · 2014Review
- Angiotensin II, sympathetic nerve activity and chronic heart failure.Heart failure reviews · 2014Review
- Organ selective regulation of sympathetic outflow by the brain Angiotensin system.Current hypertension reports · 2013Review
- Angiotensin II Stimulates Sympathetic Neurotransmission to Adipose Tissue.Physiological reports · 2013Article
- The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep.The Journal of physiology · 2013Article
- Effect of global and regional sympathetic blockade on arterial pressure during water deprivation in conscious rats.American journal of physiology. Heart and circulatory physiology · 2012Article
- Sympathetic signatures of cardiovascular disease: a blueprint for development of targeted sympathetic ablation therapies.Hypertension (Dallas, Tex. : 1979) · 2012Article
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5 authors at 1 institution in 1 country.
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Abstract
In heart failure (HF), cardiac sympathetic nerve activity (SNA; CSNA) is increased, which has detrimental effects on the heart and promotes arrhythmias and sudden death. There is evidence that the central renin-angiotensin system plays an important role in stimulating renal SNA in HF. Because SNA to individual organs is differentially controlled, we have investigated whether central angiotensin receptor blockade decreases CSNA in HF. We simultaneously recorded CSNA and renal SNA in conscious normal sheep and in sheep with HF induced by rapid ventricular pacing (ejection fraction: <40%). The effect of blockade of central angiotensin type 1 receptors by intracerebroventricular infusion of losartan (1 mg/h for 5 hours) on resting levels and baroreflex control of CSNA and renal SNA were determined. In addition, the levels of angiotensin receptors in central autonomic nuclei were determined using autoradiography. Sheep in HF had a large increase in CSNA (43±2 to 88±3 bursts per 100 heart beats; P<0.05) and heart rate, with no effect on renal SNA. In HF, central infusion of losartan for 5 hours significantly reduced the baseline levels of CSNA (to 69±5 bursts per 100 heart beats) and heart rate. Losartan had no effect in normal animals. In HF, angiotensin receptor levels were increased in the paraventricular nucleus and supraoptic nucleus but reduced in the area postrema and nucleus tractus solitarius. In summary, infusion of losartan reduced the elevated levels of CNSA in an ovine model of HF, indicating that central angiotensin receptors play a critical role in stimulating the increased sympathetic activity to the heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.