Evidence map›Paper›PMID 22311825›Full record

ArticleProteomics2012

Search engine processor: Filtering and organizing peptide spectrum matches.

Paulo C Carvalho, Juliana S G Fischer, Tao Xu, Daniel Cociorva, Tiago S Balbuena, Richard H Valente, Jonas Perales, John R Yates, Valmir C Barbosa

Abstract read
In one paragraph

Article in Proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Article
  2. Cellular and molecular responses ofMicrobiology spectrum · 2026
    Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Pathogenic diversity ofCell surface (Amsterdam, Netherlands) · 2025
    Article
  8. An anti-adhesive peptide found in extracellular vesicles fromCell surface (Amsterdam, Netherlands) · 2025
    Article
  9. Article
  10. Comparative Gut Proteome ofMicroorganisms · 2025
    Article
  11. Article
  12. Heme metabolism in Strigomonas culicis: Implications of HThe Journal of biological chemistry · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. SpliceProt 2.0: A Sequence Repository of Human, Mouse, and Rat Proteoforms.International journal of molecular sciences · 2024
    Article
  18. Article
  19. Mebendazole InhibitsJournal of fungi (Basel, Switzerland) · 2023
    Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paulo C CarvalhoLaboratory for Toxinology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com
Juliana S G Fischer
Tao Xu
Daniel Cociorva
Tiago S Balbuena
Richard H Valente
Jonas Perales
John R Yates
Valmir C Barbosa

Funding

ZDS2P REGULATES SWE1P-DEPENDENT POLARIZED CELL GROWTH IN S CEREVISIAEP41RR011823 · NCRR · UNIVERSITY OF WASHINGTON · PI DAVIS, TRACY · 1996 to 2011
$24.7M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
Quantitative Proteome Analysis of Brain DevelopmentR01MH067880 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2003 to 2017
$7.1M
NCRR NIH HHS P41 RR011823NIGMS NIH HHS P41 GM103533NIMH NIH HHS R01 MH067880
6 · The paper itself

Abstract

The search engine processor (SEPro) is a tool for filtering, organizing, sharing, and displaying peptide spectrum matches. It employs a novel three-tier Bayesian approach that uses layers of spectrum, peptide, and protein logic to lead the data to converge to a single list of reliable protein identifications. SEPro is integrated into the PatternLab for proteomics environment, where an arsenal of tools for analyzing shotgun proteomic data is provided. By using the semi-labeled decoy approach for benchmarking, we show that SEPro significantly outperforms a commercially available competitor.

Indexed as

AlgorithmsDatabases, ProteinSoftwareAnimalsBayes TheoremChromatography, LiquidDatabase Management SystemsMicePeptide FragmentsProteinsProteomicsTandem Mass SpectrometryUser-Computer InterfacePeptide FragmentsProteins

Identifiers

PMID22311825
PMCPMC3334471

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.