Evidence map›Paper›PMID 22311420›Full record

Trial reportDiabetologia2012

Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes.

C R Mikus, D J Oberlin, J Libla, L J Boyle, J P Thyfault

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00954109 nacompletednot on this map

Physical Inactivity and Insulin Resistance in Skeletal Muscle

TypeinterventionalSponsorUS Department of Veterans AffairsRan2009 to 2010Enrolled11ConditionsInsulin ResistanceArmsExercise
NCT00972452 nacompletednot on this map

Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2009 to 2010Enrolled30ConditionsType 2 Diabetes, Insulin ResistanceArmsExercise
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

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  20. Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C R MikusDepartment of Nutrition and Exercise Physiology, 10A McKee, University of Missouri, Columbia, MO, 65211, USA.
D J Oberlin
J Libla
L J Boyle
J P Thyfault
University of Missouri · US

Funding

Exercise &Health: Integration from Molecule to PatientT32AR048523 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI TERJUNG, RONALD L · 2003 to 2013
$2.5M
NIAMS NIH HHS T32 AR-048523NIAMS NIH HHS T32 AR048523
6 · The paper itself

Abstract

aims/hypothesisCardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to the OGTT. The purpose of this study was to determine whether short-term exercise training improves PPG and glycaemic control in free-living patients with type 2 diabetes, independently of the changes in fitness, adiposity and energy balance often associated with chronic exercise training.

methodsUsing continuous glucose monitors, PPG was quantified in previously sedentary patients with type 2 diabetes not using exogenous insulin (n = 13, age 53 ± 2 years, HbA(1c) 6.6 ± 0.2% (49.1 ± 1.9 mmol/mol)) during 3 days of habitual activity and during the final 3 days of a 7 day aerobic exercise training programme (7D-EX) which does not elicit measurable changes in cardiorespiratory fitness or body composition. Diet was standardised across monitoring periods, with modifications during 7D-EX to offset increases in energy expenditure. OGTTs were performed on the morning following each monitoring period.

results7D-EX attenuated PPG (p < 0.05) as well as the frequency, magnitude and duration of glycaemic excursions (p < 0.05). Conversely, average 24 h blood glucose did not change, nor did glucose, insulin or C-peptide responses to the OGTT. CONCLUSIONS/

interpretation7D-EX attenuated glycaemic variability and PPG in free-living patients with type 2 diabetes but did not significantly alter responses to the laboratory-based OGTT. These effects appeared to be independent of changes in fitness, body composition or energy balance. ClinicalTrials.gov numbers: NCT00954109 and NCT00972452.

fundingThis project was funded by the University of Missouri Institute for Clinical and Translational Sciences (CRM), NIH grant T32 AR-048523 (CRM), Diabetes Action Research and Education Foundation (JPT). Medtronic supplied CGMS sensors at a discounted rate.

Indexed as

AdiposityBlood GlucoseBody Mass IndexC-PeptideDiabetes Mellitus, Type 2DietExerciseExercise TherapyFemaleGlucose Tolerance TestGlycated HemoglobinHumansInsulinMaleMiddle AgedPostprandial PeriodBlood GlucoseC-PeptideGlycated Hemoglobinhemoglobin A1c protein, humanInsulin

Identifiers

PMID22311420
PMCPMC4500040
OpenAlexW2021448591

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.