ArticleDiabetologia2012
Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Exploring pancreatic beta-cell subgroups and their connectivity.Nature metabolism · 2024Review
- Integrated transcriptomics contrasts fatty acid metabolism with hypoxia response in β-cell subpopulations associated with glycemic control.BMC genomics · 2023Article
- Laminin matrix regulates beta-cell FGFR5 expression to enhance glucose-stimulated metabolism.Scientific reports · 2022Article
- Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.American journal of physiology. Endocrinology and metabolism · 2021Review
- The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets.Frontiers in bioengineering and biotechnology · 2021Article
- Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease.Frontiers in physiology · 2021Review
- Transcriptional profiles of human islet and exocrine endothelial cells in subjects with or without impaired glucose metabolism.Scientific reports · 2020Article
- Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes.Communications biology · 2020Article
- Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack.Physiological reports · 2020Article
- DecreasedJournal of the Endocrine Society · 2019Article
- Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.Diabetologia · 2019Article
- Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.Endocrine connections · 2017Article
- Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants.Current diabetes reports · 2017Review
- Impact of islet architecture on β-cell heterogeneity, plasticity and function.Nature reviews. Endocrinology · 2016Review
- Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells.Diabetologia · 2016Article
- Serotonin competence of mouse beta cells during pregnancy.Diabetologia · 2016Review
- Pancreatic islet blood flow and its measurement.Upsala journal of medical sciences · 2016Review
- New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.Diabetologia · 2015Review
- Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation.Diabetologia · 2015Article
- The dark side of islet vasculature.Diabetologia · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe blood perfusion of individual pancreatic islets is highly variable, with a subgroup of islets having high perfusion and blood vessels responsive to further blood flow increase induced by glucose. This study tested the hypothesis that there is heterogeneity between islets with regard to beta cell proliferation, function and gene expression based on differences in their blood perfusion.
methodsFluorescent microspheres were injected into the ascending aorta, and then microsphere-containing and non-microsphere-containing pancreatic islets were isolated for investigation. By this procedure, the 5% of islets with the greatest blood perfusion were identified for study. Islet endothelial cells were isolated separately to investigate the role of improved vascular support in the observed differences.
resultsThe vascular network was found to be more dense and tortuous in microsphere-containing than other islets. The most highly blood-perfused islets also had a higher rate of beta cell proliferation, superior beta cell function and a markedly different gene expression from other islets. Cultured islets exposed to islet endothelial cell products had a similarly increased beta cell proliferation rate, yet significantly fewer changes in gene expression than observed in the most highly blood-perfused islets. CONCLUSIONS/
interpretationA novel heterogeneity between islets was observed, with superior beta cell proliferation, function and gene expression in a subpopulation of islets identified by high blood perfusion. In contrast with a previously described population of low-oxygenated, sleeping islets, which are recruited into functionality when needed, the presently described heterogeneity is shown to remain in vitro after islet isolation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.