ArticleDigestive diseases and sciences2012
ASCA IgG and CBir antibodies are associated with the development of Crohn's disease and fistulae following ileal pouch-anal anastomosis.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Risks Factors Associated with the Development of Crohn's Disease After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: A Systematic Review and Meta-Analysis.Journal of Crohn's & colitis · 2023Pooled it
- The Incidence and Definition of Crohn's Disease of the Pouch: A Systematic Review and Meta-analysis.Inflammatory bowel diseases · 2019Pooled it
- A narrative review of the ileal pouch in pediatric inflammatory bowel disease and familial adenomatous polyposis.Journal of pediatric gastroenterology and nutrition · 2025Review
- Early Pouchitis Is Associated With Crohn's Disease-like Pouch Inflammation in Patients With Ulcerative Colitis.Inflammatory bowel diseases · 2022Article
- Disease Monitoring of the Ileoanal Pouch: How to Utilize Biomarkers, Imaging, and Pouchoscopy.Current gastroenterology reports · 2022Review
- Clinical Challenge: From Ulcerative Colitis to Crohn's Disease-Like Pouch Inflammation.Digestive diseases and sciences · 2021Article
- The MYTHS ofJapanese journal of gastroenterology and hepatology · 2020Article
- Association Between Serological Markers and Crohn's Disease Activity.Journal of clinical medicine research · 2020Article
- De Novo Crohn's Disease of the Pouch in Children Undergoing Ileal Pouch-Anal Anastomosis for Ulcerative Colitis.Journal of pediatric gastroenterology and nutrition · 2019Article
- Patchy colitis, and young age at diagnosis and at the time of surgery predict subsequent development of Crohn's disease after ileal pouch-anal anastomosis surgery for ulcerative colitis.JGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Serological, genetic and clinical associations with increased health-care resource utilization in inflammatory bowel disease.Journal of digestive diseases · 2018Article
- Review article: the pathogenesis of pouchitis.Alimentary pharmacology & therapeutics · 2016Review
- The Immunological Basis of Inflammatory Bowel Disease.Gastroenterology research and practice · 2016Review
- Diagnostic and Prognostic Microbial Biomarkers in Inflammatory Bowel Diseases.Gastroenterology · 2015Review
- Effects of age at disease onset and at treatment on serology in inflammatory bowel diseases.Digestive diseases and sciences · 2015Article
- Differential response to microbial antigens by age of diagnosis in patients with Crohn's disease.Clinical and experimental gastroenterology · 2015Article
- Is pyloric gland metaplasia in ileal pouch biopsies a marker for Crohn's disease?Digestive diseases and sciences · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA), postoperative complications include chronic pouchitis and development of Crohn's disease (CD) of the pouch.
aimsThe aim of this study was to determine if serologic markers obtained postoperatively are associated with the development of complications in UC patients after IPAA.
methodsA retrospective chart review was conducted of UC patients with IPAA were tested for expression of serologic markers. Complications abstracted from medical records included postoperative fistula, CD of the pouch, chronic pouchitis, and diversion or excision of the pouch.
results142 patients were enrolled, 44 of whom developed complications. Positive serologic profiles for ASCA IgG and anti-CBir1 markers were found to be associated with the development of any complication, (P = 0.017 and P = 0.002, respectively). A positive anti-CBir1 test was also found to be associated with CD of the pouch and/or fistula formation (P < 0.001). Similarly, both ASCA IgG and anti-CBir1 titers were significantly associated with postoperative IPAA complications (P = 0.034 and P = 0.001, respectively), and anti-CBir1 titers were associated with CD of the pouch and/or fistula formation (P < 0.001). Complications developed after a median follow-up of 216 months (range 1-264).
conclusionsASCA IgG and anti-CBir1 markers were associated with the development of complications after IPAA, specifically fistulae and/or CD of the pouch. The ability to identify patients at high risk for adverse outcomes may allow for early aggressive therapy, which may decrease the rate of pouch failure. A prospective study of patients with preoperative serology is ongoing.
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