ArticlePediatric nephrology (Berlin, Germany)2012
Uric acid and IGF1 as possible determinants of FGF23 metabolism in children with normal renal function.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007-2016.Lipids in health and disease · 2024Article
- Mineral Metabolism in Children: Interrelation between Vitamin D and FGF23.International journal of molecular sciences · 2023Review
- Association between serum uric acid and α-klotho protein levels in the middle-aged population.Aging · 2022Article
- Bone Fragility Fractures in CKD Patients.Calcified tissue international · 2021Review
- Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients.Renal failure · 2019Article
- Association between serum uric acid and bone health in adolescents.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Liver phosphorus content and liver function in states of phosphorus deficiency in transition dairy cows.PloS one · 2019Article
- Insulin suppresses the production of fibroblast growth factor 23 (FGF23).Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diabetes Complications in Childhood Diabetes-New Biomarkers and Technologies.Current pediatrics reports · 2015Article
- Association between decreased klotho blood levels and organic growth hormone deficiency in children with growth impairment.PloS one · 2014Article
- Associations between fibroblast growth factor 23 and cardiac characteristics in pediatric heart failure.Pediatric nephrology (Berlin, Germany) · 2013Article
- Excessive fructose intake causes 1,25-(OH)(2)D(3)-dependent inhibition of intestinal and renal calcium transport in growing rats.American journal of physiology. Endocrinology and metabolism · 2013Article
- Chronic kidney disease: mineral and bone disorder in children.Seminars in nephrology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFibroblast growth factor 23 (FGF23) is a phosphaturic hormone and a suppressor of renal 1α hydroxylase. Although circulating values of FGF23 are increased in early chronic kidney disease (CKD), the interplay between FGF23 levels, growth and nutritional biomarkers has not been evaluated in children with normal renal function.
methodsWe performed a secondary analysis of the cross-sectional observational INU23 study in 98 children (51 boys, mean age 10.5 ± 3.9 years) with preserved renal function (glomerular filtration rate (GFR) 114 ± 14 ml/min/1.73 m(2)).
resultsIn bivariate analyses, C-terminal FGF23 levels were positively related to phosphorus and uric acid levels. Intact FGF23 levels were positively associated with uric acid and insulin growth factor 1 (IGF1) levels, with similar results for age, body mass index (BMI), and 25OH vitamin D (25(OH)D). By multivariable analyses, 25(OH)D, uric acid, and phosphorus were independent predictors of C-terminal FGF23, while 25(OH)D, uric acid, and IGF1 were independent predictors of intact FGF23.
conclusionsIn children with preserved kidney function, the association between FGF23, uric acid, and IGF1 suggests that FGF23 could be an early nutritional indicator of high protein and phosphate intake. The association between FGF23 and IGF1 also suggests a relationship between FGF23 and growth, and warrants further investigation.
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