ArticleArquivos de neuro-psiquiatria2012
Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder.
Article in Arquivos de neuro-psiquiatria, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association between TNF-α-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.Medicine · 2018Pooled it
- Exploring comorbidity networks in mild traumatic brain injury subjects through graph theory: a traumatic brain injury model systems study.BMC neurology · 2025Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
- Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder.Translational psychiatry · 2022Article
- Cytokine profile of pediatric patients with obsessive-compulsive and/or movement disorder symptoms: A review.Frontiers in pediatrics · 2022Review
- Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions.Neuroscience and biobehavioral reviews · 2021Review
- Obsessive-Compulsive Disorder With Rheumatological and Inflammatory Diseases: A Systematic Review.Cureus · 2021Review
- Obsessive-Compulsive Disorder: Autoimmunity and Neuroinflammation.Current psychiatry reports · 2019Review
- Individualized Immunological Data for Precise Classification of OCD Patients.Brain sciences · 2018Review
- Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs.Translational psychiatry · 2016Article
- Microglial Cells as a Link between Cannabinoids and the Immune Hypothesis of Psychiatric Disorders.Frontiers in neurology · 2016Review
- Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.Developmental cognitive neuroscience · 2015Article
- Neuroinflammation and psychiatric illness.Journal of neuroinflammation · 2013Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
Abstract
Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK(®) software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ(2) association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.