Evidence map›Paper›PMID 22311111›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012

Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.

J-J Body, P Bergmann, S Boonen, J-P Devogelaer, E Gielen, S Goemaere, J-M Kaufman, S Rozenberg, J-Y Reginster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Observational
  8. Review
  9. Review
  10. Article
  11. Dietary calcium intake in Brazilian preschoolers and schoolchhildren: review of the literature.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022
    Review
  12. Article
  13. Article
  14. Evidence of patient beliefs, values, and preferences is not provided in osteoporosis clinical practice guidelines.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Impact and risk factors of post-stroke bone fracture.World journal of experimental medicine · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J-J BodyDepartment of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
P Bergmann
S Boonen
J-P Devogelaer
E Gielen
S Goemaere
J-M Kaufman
S Rozenberg
J-Y Reginster

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledDrugs used for the prevention and the treatment of osteoporosis exert various favourable and unfavourable extra-skeletal effects whose importance is increasingly recognized notably for treatment selection.

introductionThe therapeutic armamentarium for the prevention and the treatment of osteoporosis is increasingly large, and possible extra-skeletal effects of available drugs could influence the choice of a particular compound.

methodsThe present document is the result of a national consensus, based on a systematic and critical review of the literature.

resultsObservational research has suggested an inverse relationship between calcium intake and cardiovascular diseases, notably through an effect on blood pressure, but recent data suggest a possible deleterious effect of calcium supplements on cardiovascular risk. Many diverse studies have implicated vitamin D in the pathogenesis of clinically important non-skeletal functions or diseases, especially muscle function, cardiovascular disease, autoimmune diseases and common cancers. The possible effects of oral or intravenous bisphosphonates are well-known. They have been associated with an increased risk of oesophageal cancer or atrial fibrillation, but large-scale studies have not found any association with bisphosphonate use. Selective oestrogen receptor modulators have demonstrated favourable or unfavourable extra-skeletal effects that vary between compounds. Strontium ranelate has a limited number of non-skeletal effects. A reported increase in the risk of venous thromboembolism is not found in observational studies, and very rare cases of cutaneous hypersensitivity reactions have been reported. Denosumab has been introduced recently, and its extra-skeletal effects still have to be assessed.

conclusionSeveral non-skeletal effects of bone drugs are well demonstrated and influence treatment choices.

Indexed as

AgedAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBone Density Conservation AgentsCalciumCardiovascular DiseasesConsensusDenosumabDietary SupplementsDiphosphonatesFemaleHumansMaleMiddle AgedMuscle, SkeletalNeoplasmsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBone Density Conservation AgentsCalciumDenosumabDiphosphonatesOrganometallic CompoundsSelective Estrogen Receptor Modulatorsstrontium ranelateThiophenesVitamin D

Identifiers

PMID22311111
PMCPMC3273686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.