ArticleMolecular biology reports2012
Characterization and expression analysis of prohibitin in the testis of Chinese mitten crab Eriocheir sinensis.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 30 citations in OpenAlex.
- The Effect of Prohibitins on Mitochondrial Function duringInternational journal of molecular sciences · 2023Article
- Characterization of Mitochondrial Prohibitin inInternational journal of molecular sciences · 2022Article
- Hypo-hydroxymethylation of rRNA genes in the precocious Eriocheir sinensis testes revealed using hMeDIP-seq.Scientific reports · 2017Article
- H3K9ac involved in the decondensation of spermatozoal nuclei during spermatogenesis in Chinese mitten crab Eriocheir sinensis.Cytotechnology · 2017Article
- Transcriptome using Illumina sequencing reveals the traits of spermatogenesis and developing testes in Eriocheir sinensis.PloS one · 2017Article
- Molecular characterization and expression analysis of a KIFC1-like kinesin gene in the testis of Eumeces chinensis.Molecular biology reports · 2013Article
- Identification of a sex-linked SNP marker in the salmon louse (Lepeophtheirus salmonis) using RAD sequencing.PloS one · 2013Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Prohibitin plays a key role in maintaining mitochondrial membrane integrity and retaining its normal function. We have initially cloned and sequenced the cDNA of prohibitin from testis of the crab Eriocheir sinensis. The 1,357 bp Prohibitin cDNA comprises a 105 bp 5' untranslated region, a 427 bp 3' untranslated region and a 825 bp open reading frame. Protein alignment substantiates that the Prohibitin has 70.2, 69.8, 70.5, 70.9, 72.4, 70.6 and 74.9% identity with its homologues in Mus musculus, Homo sapiens, Gallus gallus, Danio rerio, Xenopus tropicalis, Drosophila mojavensis and Aedes aegypti, respectively. In situ hybridization revealed that the Prohibitin mRNA was mainly localized around the proacrosomal vesicle and nucleus membrane in early-stage spermatid. In the following middle stage, Prohibitin mRNA was situated inside the invaginated region of half-moon-like nucleus and surrounded the proacrosomal vesicle. In late-stage spermatid, the mRNA was aggregated in the acrosomal tubule, the band between the acrosome and cup-like nucleus, remanent cytoplasm as well. In the mature sperm, mRNA was only found in the acrosomal tubule and the limited space between the nucleus and acrosome. Therefore, we presume that Prohibitin may fulfill critical functions in the spermiogenesis of Eriocheir sinensis.
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