ArticleMolecular biology reports2012
Analysis of polymorphism within POU1F1 gene in relation to milk production traits in dairy Sarda sheep breed.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Association of DGAT1 and POU1F1 Gene Polymorphisms With the Milk Traits in the Cross-Bred Hamdani Sheep Bred Under Extensive Management.Veterinary medicine and science · 2025Article
- Genetic Characterization of Myf5 and POU1F1 Genes in Different Egyptian Local Rabbit Breeds and Their Association with Growth Traits.Biochemical genetics · 2024Article
- Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats.Archives animal breeding · 2023Article
- Article
- Associations between genetic variants of theArchives animal breeding · 2019Article
- Genome-Wide Association Studies Identify Candidate Genes for Coat Color and Mohair Traits in the Iranian Markhoz Goat.Frontiers in genetics · 2018Article
- Associations of POU1F1 gene polymorphisms and protein structure changes with growth traits and blood metabolites in two Iranian sheep breeds.Journal of genetics · 2014Article
- Association of pituitary specific transcription factor-1 (POU1F1) gene polymorphism with growth and biometric traits and blood metabolites in Iranian Zel and Lori-Bakhtiari sheep.Molecular biology reports · 2014Article
- Ovine insulin induced-gene-2: molecular characterization, polymorphisms and association with milk traits.Molecular biology reports · 2014Article
- Polymorphism of sheep POU1F1 gene exon 6 and 3'UTR region and their association with milk production traits.Iranian journal of veterinary research · 2014Article
- Identification of novel SNPs in the Sarda breed goats POU1F1 gene and their association with milk productive performance.Molecular biology reports · 2013Article
- Polymorphisms and expression of the chicken POU1F1 gene associated with carcass traits.Molecular biology reports · 2012Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ovine POU1F1 gene is localized on chromosome 1 and it contains five introns and six exons. In different mammalian species some mutations in different exons are associated with different production traits. The aim of our research was to study the POU1F1 gene nucleotide sequence to detect possible polymorphisms and their relationships with milk productive traits in Sarda breed sheep. The study had been conducted on 140 ewes, 4 or 5 years old coming from a farm located in Sardinia. All the animals were multiparous, lactating and in their third to fifth lactation. Individual milk yield had been recorded monthly and for each sample fat, protein, casein, lactose, and somatic cell count values were analysed. A jugular blood sample was collected from each ewe to perform genomic DNA extraction. PCR, SSCP and sequencing analysis were carried out to examine the six exons to highlight possible SNPs. One-way ANOVA was used to analyse association of variants with milk yield and/or its composition. Two novel SNP were found: 121 C>T in the 5'UTR of the fourth intron fragment and 249 G>A in the 3'UTR of the sixth exon fragment. The statistical analysis did not shown association between milk productive traits and the found polymorphisms. However, further investigations about the promoter region or the prophet genes, like the PROP-1, could clarify its exact role in regulating the productive traits in sheep.
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