ReviewRadiation and environmental biophysics2012
Computed tomographies and cancer risk in children: a literature overview of CT practices, risk estimations and an epidemiologic cohort study proposal.
Review in Radiation and environmental biophysics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Risk of malignancy associated with head and neck CT in children: a systematic review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2014Pooled it
- Academic achievement after a CT examination toward the head in childhood: Follow up of a randomized controlled trial.PloS one · 2023Trial
- Retroperitoneal dedifferentiated liposarcoma with colon infiltration: a case report and literature review.Frontiers in oncology · 2025Article
- Synchronous retroperitoneal liposarcoma and gastric adenocarcinoma: A rare case report.Radiology case reports · 2024Article
- The Prognostic Value of Ultrasound Findings in Preoperatively Distinguishing between Uncomplicated and Complicated Types of Pediatric Acute Appendicitis Based on Correlation with Intraoperative and Histopathological Findings.Diagnostics (Basel, Switzerland) · 2022Article
- Identification of Genetic Predispositions Related to Ionizing Radiation in Primary Human Skin Fibroblasts From Survivors of Childhood and Second Primary Cancer as Well as Cancer-Free Controls: Protocol for the Nested Case-Control Study KiKme.JMIR research protocols · 2021Article
- Epidemiological studies of CT scans and cancer risk: the state of the science.The British journal of radiology · 2021Review
- Clinical pediatric positron emission tomography/magnetic resonance program: a guide to successful implementation.Pediatric radiology · 2020Review
- Reference intervals of mesenteric lymph node size according to lymphocyte counts in asymptomatic children.PloS one · 2020Article
- Giant retroperitoneal liposarcoma: A case report and literature review.Journal of Taibah University Medical Sciences · 2019Article
- Comparative Volume Analysis of Alveolar Defects by 3D Simulation.Journal of clinical medicine · 2019Article
- ORGAN DOSE ESTIMATION ACCOUNTING FOR UNCERTAINTY FOR PEDIATRIC AND YOUNG ADULT CT SCANS IN THE UNITED KINGDOM.Radiation protection dosimetry · 2019Article
- Cohort Profile: the EPI-CT study: a European pooled epidemiological study to quantify the risk of radiation-induced cancer from paediatric CT.International journal of epidemiology · 2019Article
- Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Impact of Low-Dose Computed Tomography on Computed Tomography Orders and Scan Length.Ochsner journal · 2019Article
- Diagnostic Utility of Ultrasonography for Duodenal Ulcers in Pediatric Cases in Japan.Frontiers in pediatrics · 2019Article
- Computed tomography use in a large Italian region: trend analysis 2004-2014 of emergency and outpatient CT examinations in children and adults.European radiology · 2018Article
- Course of acute nonspecific mesenteric lymphadenitis: single-center experience.European journal of pediatrics · 2018Article
- Estimation of effective doses in pediatric X-ray computed tomography examination.Experimental and therapeutic medicine · 2017Article
- Pediatric computed tomography practice in Japanese university hospitals from 2008-2010: did it differ from German practice?Journal of radiation research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation protection is a topic of great public concern and of many scientific investigations, because ionizing radiation is an established risk factor for leukaemia and many solid tumours. Exposure of the public to ionizing radiation includes exposure to background radiation, as well as medical and occupational exposures. A large fraction of the exposure from diagnostic procedures comes from medical imaging. Computed tomography (CT) is the major single contributor of diagnostic radiation exposure. An increase in the use of CTs has been reported over the last decades in many countries. Children have smaller bodies and lower shielding capacities, factors that affect the individual organ doses due to medical imaging. Several risk models have been applied to estimate the cancer burden caused by ionizing radiation from CT. All models predict higher risks for cancer among children exposed to CT as compared to adults. However, the cancer risk associated with CT has not been assessed directly in epidemiological studies. Here, plans are described to conduct an historical cohort study to investigate the cancer incidence in paediatric patients exposed to CT before the age of 15 in Germany. Patients will be recruited from radiology departments of several hospitals. Their individual exposure will be recorded, and time-dependent cumulative organ doses will be calculated. Follow-up for cancer incidence via the German Childhood Cancer Registry will allow computation of standardized incidence ratios using population-based incidence rates for childhood cancer. Dose-response modelling and analyses for subgroups of children based on the indication for and the result of the CT will be performed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.