Evidence map›Paper›PMID 22310869›Full record

ArticleIntensive care medicine2012

Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems.

Annika Reintam Blaser, Manu L N G Malbrain, Joel Starkopf, Sonja Fruhwald, Stephan M Jakob, Jan De Waele, Jan-Peter Braun, Martijn Poeze, Claudia Spies

6 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 284 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02318134 phase2completednot on this mapstarted 2017, after this paper: background citation

Fecal Microbiota Transplantation in SAP（Severe Acute Pancreatitis）Patients With Intestinal Barrier Dysfunction

TypeinterventionalSponsorThe First Affiliated Hospital of Nanchang UniversityRan2017 to 2019Enrolled60ConditionsAcute Pancreatitis, Intestinal Bacteria Flora Disturbance, Intestinal Dysfunction, Fecal Microbiota TransplantationArmsFecal Microbiota Transplantation, normal saline
NCT02732301 unknown statusnot on this mapstarted 2015, after this paper: background citation

Gastrointestinal Dysfunktion Efter hjärtkirurgi - förekomst Samt sökande Efter Nya biomarkörer

TypeobservationalSponsorRegion Örebro CountyRan2015 to 2022Enrolled501ConditionsThoracic Surgical Procedures, Gastrointestinal Tract, Cardiopulmonary Bypass, Biomarkers
NCT02977286 phase4terminatednot on this mapstarted 2017, after this paper: background citation

Impact of Naloxegol on Prevention of Lower GI Tract Paralysis in Critically Ill Adults Initiated on Scheduled Intravenous Opioid Therapy: A Randomized, Double-Blind, Placebo-Controlled, Phase II, Single-Center, Proof of Concept Study

TypeinterventionalSponsorTufts Medical CenterRan2017 to 2019Enrolled12ConditionsConstipationArmsNaloxegol Oral Tablet, Placebo Oral Tablet, Docusate Sodium 100 Mg oral capsule [Colace], Senna 217 Mg Oral Tablet, Polyethylene Glycols
NCT03406494 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Southern Medical University Clinical Research Project Initiative：Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis

TypeinterventionalSponsorZhujiang HospitalRan2018 to 2021Enrolled800ConditionsSepsisArmsEarly multicomponent physical therapy program
NCT04462211 nacompletednot on this mapstarted 2019, after this paper: background citation

Pilot Study of the Preparation and Implementation of a Constipation Bundle & Management Protocol and the Effect of Adherence in Reducing the Incidence of Constipation in Critically Ill Patients of a University Hospital

TypeinterventionalSponsorUniversity of ChileRan2019 to 2020Enrolled66ConditionsConstipation, Critical Illness, Constipation Drug InducedArmsImplementation of management pharmacological protocol of constipation, Implementation of bundle of prevention and non-pharmacological management
NCT06697405 completednot on this mapstarted 2024, after this paper: background citation

Incidence, Risk Factors, and Outcomes of Gastrointestinal Complications in Patients Undergoing Heart Valve Replacement With Cardiopulmonary Bypass

TypeobservationalSponsorHepatopancreatobiliary Surgery Institute of Gansu ProvinceRan2024 to 2025Enrolled1,444ConditionsValvular DiseaseArmsProlonged ≥ 120 minutes
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Prevalence and risk factors for feeding intolerance in geriatric patients following nasogastric tube nutrition: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  7. Guideline
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  12. Monitoring of gastric residual volume during enteral nutrition.The Cochrane database of systematic reviews · 2021
    Pooled it
  13. Guideline
  14. Trial
  15. Trial
  16. Trial
  17. Effects of permissive hypocaloricWorld journal of gastroenterology · 2021
    Trial
  18. Trial
  19. Article
  20. Review

224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annika Reintam BlaserClinic of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, 51014 Tartu, Estonia. annika.reintam@ut.ee
Manu L N G Malbrain
Joel Starkopf
Sonja Fruhwald
Stephan M Jakob
Jan De Waele
Jan-Peter Braun
Martijn Poeze
Claudia Spies

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAcute gastrointestinal (GI) dysfunction and failure have been increasingly recognized in critically ill patients. The variety of definitions proposed in the past has led to confusion and difficulty in comparing one study to another. An international working group convened to standardize the definitions for acute GI failure and GI symptoms and to review the therapeutic options.

methodsThe Working Group on Abdominal Problems (WGAP) of the European Society of Intensive Care Medicine (ESICM) developed the definitions for GI dysfunction in intensive care patients on the basis of the available evidence and current understanding of the pathophysiology.

resultsDefinitions for acute gastrointestinal injury (AGI) with its four grades of severity, as well as for feeding intolerance syndrome and GI symptoms (e.g. vomiting, diarrhoea, paralysis, high gastric residual volumes) are proposed. AGI is a malfunctioning of the GI tract in intensive care patients due to their acute illness. AGI grade I = increased risk of developing GI dysfunction or failure (a self-limiting condition); AGI grade II = GI dysfunction (a condition that requires interventions); AGI grade III = GI failure (GI function cannot be restored with interventions); AGI grade IV = dramatically manifesting GI failure (a condition that is immediately life-threatening). Current evidence and expert opinions regarding treatment of acute GI dysfunction are provided.

conclusionsState-of-the-art definitions for GI dysfunction with gradation as well as management recommendations are proposed on the basis of current medical evidence and expert opinion. The WGAP recommends using these definitions for clinical and research purposes.

Indexed as

Critical CareCritical IllnessGastrointestinal DiseasesGastrointestinal TractHumansSeverity of Illness IndexTerminology as Topic

Identifiers

PMID22310869
PMCPMC3286505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.