ReviewNature reviews. Endocrinology2012
Intensive insulin therapy in the ICU--reconciling the evidence.
Review in Nature reviews. Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized Trial.JPEN. Journal of parenteral and enteral nutrition · 2019Trial
- Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins.BMC pulmonary medicine · 2014Trial
- The glucoregulatory benefits of glucagon-like peptide-1 (7-36) amide infusion during intensive insulin therapy in critically ill surgical patients: a pilot study.Critical care medicine · 2014Trial
- Accuracy of subcutaneous continuous glucose monitoring in critically ill adults: improved sensor performance with enhanced calibrations.Diabetes technology & therapeutics · 2014Trial
- Critical illness induces nutrient-independent adipogenesis and accumulation of alternatively activated tissue macrophages.Critical care (London, England) · 2013Trial
- Feasibility of fully automated closed-loop glucose control using continuous subcutaneous glucose measurements in critical illness: a randomized controlled trial.Critical care (London, England) · 2013Trial
- Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study.Critical care (London, England) · 2012Trial
- Article
- Artificial Neural Network Algorithms to Predict Resting Energy Expenditure in Critically Ill Children.Nutrients · 2021Article
- Personalized nutrition approach in pediatrics: a narrative review.Pediatric research · 2021Review
- Accuracy of Blood Glucose Measurement and Blood Glucose Targets.Journal of diabetes science and technology · 2020Review
- Critical Care Management of Stress-Induced Hyperglycemia.Current diabetes reports · 2018Review
- Effect of glycaemic control on complications following cardiac surgery: literature review.Journal of cardiothoracic surgery · 2018Review
- The intensive care medicine research agenda in nutrition and metabolism.Intensive care medicine · 2017Review
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Continuous glucose monitoring on the ICU using a subcutaneous sensor.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2015Article
- The benefits of tight glycemic control in critical illness: Sweeter than assumed?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Review
- Year in review 2013: Critical Care--metabolism.Critical care (London, England) · 2014Review
- Glucose control in the ICU: is there a time for more ambitious targets again?Journal of diabetes science and technology · 2014Review
- What's new in glucose control in the ICU?Intensive care medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperglycaemia during critical illness unequivocally correlates with adverse outcome. Three proof-of-concept randomized controlled trials have shown that preventing hyperglycaemia in patients admitted to the intensive care unit (ICU) reduces organ failure and mortality. A subsequent multicentre, randomized controlled trial found that targeting normoglycaemia in this patient population does not affect organ function differently than targeting an intermediate glucose level (7.8-10.0 mmol/l). However, an intermediate glucose target evoked less hypoglycaemia and, for currently unexplained reasons, also fewer deaths than a normoglycaemic target. Moreover, tolerating a caloric deficit, rather than providing nutrients parenterally, accelerated recovery from critical illness in the presence of normoglycaemia. Whether macronutrient restriction renders moderate hyperglycaemia less harmful remains to be investigated. Hence, if adequate monitoring tools and expertise are available, normoglycaemia remains the only proven effective target for insulin treatment of hyperglycaemia in ICU patients. However, if these conditions are not fulfilled in clinical practice, is an intermediate target range preferable? In the absence of hard evidence, common sense supports such an intermediate blood glucose target.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.