Evidence map›Paper›PMID 22310816›Full record

ReviewThe Indian journal of medical research2011

Low-cost assays for monitoring HIV infected individuals in resource-limited settings.

Pachamuthu Balakrishnan, Hussain Syed Iqbal, Saravanan Shanmugham, Janardhanan Mohanakrishnan, Sunil S Solomon, Kenneth H Mayer, Suniti Solomon

Open access · diamondAbstract readReview
In one paragraph

Review in The Indian journal of medical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Assessment of laboratory test utilization for HIV/AIDS care in urban ART clinics of Lilongwe, Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2014
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Pachamuthu BalakrishnanYRG Centre for AIDS Research & Education, Voluntary Health Services, Taramani, Chennai, India. bala@yrgcare.org
Hussain Syed Iqbal
Saravanan Shanmugham
Janardhanan Mohanakrishnan
Sunil S Solomon
Kenneth H Mayer
Suniti Solomon
YR Gaitonde Centre for AIDS Research and Education · INBrown University · USVoluntary Health Services Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Use of a combination of CD4 counts and HIV viral load testing in the management of antiretroviral therapy (ART) provides higher prognostic estimation of the risk of disease progression than does the use of either test alone. The standard methods to monitor HIV infection are flow cytometry based for CD4+ T cell count and molecular assays to quantify plasma viral load of HIV. Commercial assays have been routinely used in developed countries to monitor ART. However, these assays require expensive equipment and reagents, well trained operators, and established laboratory infrastructure. These requirements restrict their use in resource-limited settings where people are most afflicted with the HIV-1 epidemic. With the advent of low-cost and/or low-tech alternatives, the possibility of implementing CD4 count and viral load testing in the management of ART in resource-limited settings is increasing. However, an appropriate validation should have been done before putting them to use for patient testing.

Indexed as

Developing CountriesHIV-1CD4 Lymphocyte CountDisease ProgressionHIV InfectionsHumansMonitoring, ImmunologicPrognosisViral Load

Identifiers

PMID22310816
PMCPMC3284092
OpenAlexW2131724078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.