ArticleMedical care2012
Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact.
72 registry-linked trialsAbstract read
In one paragraph
Article in Medical care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 72 registered trials, which are not on this map. Cited by 2,548 papers, 4 of them syntheses that pooled it.
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2,548citing papers in PubMed, 4 pooled it
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2,548 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Clinical Surveillance Technologies in Nonintensive Care Unit Hospital Settings: Systematic Review and Bayesian Network Meta-Analysis of Randomized Trials.Journal of medical Internet research · 2026Pooled it
- Strengthening primary care facility management: a systematic review of management interventions, implementation strategies, and outcomes in six sub-Saharan African countries.BMC primary care · 2026Pooled it
- Prehabilitation for cancer surgery: a systematic review of qualitative literature from experienced stakeholders.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Implementing mental health interventions in perinatal home visiting programs: a systematic review of the literature.Archives of women's mental health · 2026Pooled it
- Pediatric Literacy Promotion for Latino Families by Texts and Referrals: A 3-Arm RCT.Pediatrics · 2026Trial
- Implementation of a patient-centred complex intervention to improve Initial Medication Adherence to cardiovascular disease and diabetes treatments in primary care (the IMA-cRCT study): a mixed-methods process evaluation.BMJ quality & safety · 2026Trial
- Deimplementation of inappropriate feeding practices in early care and education: a Hybrid Type 3 cluster-randomized trial.Implementation science : IS · 2026Trial
- Text Message Delivery of a Digital Tool for Reproductive Health Discussions in Primary Care: A Cluster Randomized Clinical Trial.JAMA network open · 2026Trial
- Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Phone-based screening versus home-based screening after tuberculosis in India (TB Aftermath): a multicentre, open-label, randomised, controlled, non-inferiority trial.The Lancet. Global health · 2026Trial
- Trial
- Comparing different forms of structured follow-up support in the treatment of multiple health risks for chronic disease: a randomized controlled trial protocol.Implementation science : IS · 2026Trial
- Implementation and Effectiveness of an Enhanced Recovery Protocol for Children Undergoing Surgery: The ENRICH-US Stepped-Wedge Cluster-Randomized Trial.JAMA surgery · 2026Trial
- Effectiveness of a Transdiagnostic Emotion-Focused Treatment in Clinical Care: A Sequential Single-Case Experimental Design.European journal of pain (London, England) · 2026Trial
- Hybrid type 1 randomized controlled trial of technology-assisted stepped care behavioral health intervention for caregivers and children following pediatric traumatic injury.Contemporary clinical trials · 2026Trial
- Implementation of an Internet-based psychological intervention for the treatment of mild depression in primary care: a hybrid effectiveness-implementation approach.BMC public health · 2026Trial
- Mediators and moderators of successful population-level weight management in primary care: results from the PATHWEIGH cluster-randomized pragmatic trial.International journal of obesity (2005) · 2026Trial
- Contextual factors related to ventilator mode during an embedded randomized trial: a longitudinal survey of clinicians.BMC health services research · 2026Trial
- Measuring and increasing the brain health span across adulthood: a public health imperative.Scientific reports · 2026Trial
- Multifaceted Strategies for Hypertension Control in Low-Income Patients.The New England journal of medicine · 2026Trial
2,488 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Geoffrey M CurranCentral Arkansas Veterans Healthcare System, and Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA. currangeoffreym@uams.edu
Mark Bauer
Brian Mittman
Jeffrey M Pyne
Cheryl Stetler
Funding
Translating Depression Guidelines in Substance Abuse TxK01DA015102 · NIDA · UNIV OF ARKANSAS FOR MED SCIS · PI CURRAN, GEOFFREY M · 2003 to 2007
$665kHSRD VA MNT 05-152NIDA NIH HHS K01 DA015102NIDA NIH HHS K01 DA15102
Abstract
objectivesThis study proposes methods for blending design components of clinical effectiveness and implementation research. Such blending can provide benefits over pursuing these lines of research independently; for example, more rapid translational gains, more effective implementation strategies, and more useful information for decision makers. This study proposes a "hybrid effectiveness-implementation" typology, describes a rationale for their use, outlines the design decisions that must be faced, and provides several real-world examples.
resultsAn effectiveness-implementation hybrid design is one that takes a dual focus a priori in assessing clinical effectiveness and implementation. We propose 3 hybrid types: (1) testing effects of a clinical intervention on relevant outcomes while observing and gathering information on implementation; (2) dual testing of clinical and implementation interventions/strategies; and (3) testing of an implementation strategy while observing and gathering information on the clinical intervention's impact on relevant outcomes.
conclusionsThe hybrid typology proposed herein must be considered a construct still in evolution. Although traditional clinical effectiveness and implementation trials are likely to remain the most common approach to moving a clinical intervention through from efficacy research to public health impact, judicious use of the proposed hybrid designs could speed the translation of research findings into routine practice.
Indexed as
Public HealthComparative Effectiveness ResearchHealth Services ResearchHumansOutcome and Process Assessment, Health CareResearch DesignTranslational Research, BiomedicalUnited StatesUnited States Department of Veterans Affairs
Identifiers
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Registered trials
NCT00304915ClinicalTrials.gov
NCT02181062ClinicalTrials.gov
NCT02510313ClinicalTrials.gov
NCT02727478ClinicalTrials.gov
NCT02944786ClinicalTrials.gov
NCT03075085ClinicalTrials.gov
and 66 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.