ArticleReproductive biology and endocrinology : RB&E2012
Hyberbaric oxygen increases atresia in normal & steroid induced PCO rat ovaries.
Article in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Pharmacological effects of bile acids on polycystic ovary syndrome via the regulation of chemerin.Chinese medicine · 2025Article
- Article
- A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS.Journal of ovarian research · 2020Article
- Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model.Iranian journal of basic medical sciences · 2018Article
- Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
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8 authors at 2 institutions in 1 country.
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Abstract
backgroundIn this study, we investigated the effect of hyperbaric oxygen therapy (HBOT) on the morphology of estradiol valerate (EV) induced polycystic ovary (PCO) to find a new treatment modality for improvement of PCO.
methodsThe rats were divided into four groups. Group1, control; group 2, PCO group; group 3, PCO with HBOT group and group 4, normal ovary with HBOT. PCO was induced by a single intramuscular injection of 4 mg EV in adult cycling rats. Other rats with normal ovaries had oil injection as placebo. HBOT was applied to third and fourth groups for six weeks. Histopathologic evaluation of ovaries of all groups were performed & compared.
resultsSix weeks of HBOT was resulted in increase in follicular atresia, decrease in the number of primary, secondary, tertiary follicles and decrease in the number of fresh corpus luteum in normal rat ovary. HBOT on polycystic rat ovary, resulted in significant increase in atretic follicles which were already present.
conclusionsHBOT of six weeks itself, changed ovarian morphology in favor of atresia both in PCO group and control group. This result of aggravated follicular atresia after HBOT on EV induced PCO may be due to long-term exposure in our protocol which with this state seems to be inapplicable in the improvement of PCO morphology.
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