ArticleChemosphere2012
Heavy metals and couple fecundity, the LIFE Study.
Article in Chemosphere, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed.
- An Epidemiologic Review of Endocrine-disrupting Chemicals and Understudied Gynecologic Health Conditions Affecting Quality of Life.Current environmental health reports · 2026Review
- Validating the current duration approach for measuring infertility prevalence using novel app data from the USA.Human reproduction (Oxford, England) · 2025Article
- Measuring non-events: infertility estimation using cross-sectional, population-based data from four countries in sub-Saharan Africa.Human reproduction (Oxford, England) · 2024Article
- Exposure to Environmental Chemicals and Infertility Among US Reproductive-Aged Women.International journal of environmental research and public health · 2024Article
- Associations between exposure to cadmium, lead, mercury and mixtures and women's infertility and long-term amenorrhea.Archives of public health = Archives belges de sante publique · 2023Article
- Does Air Pollution Impact on Semen Parameters? Findings from a Real-Life, Cross-Sectional Study in Italian Infertile Men.The world journal of men's health · 2023Article
- An Assessment of Metallothionein-Cadmium Binding in Rat Uterus after Subchronic Exposure Using a Long-Term Observation Model.International journal of molecular sciences · 2022Article
- An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility.International journal of environmental research and public health · 2022Review
- Does short-term, airborne lead exposure during pregnancy affect birth outcomes? Quasi-experimental evidence from NASCAR's deleading policy.Environment international · 2022Article
- Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis.Human reproduction open · 2022Review
- Metal(loid)s and human semen quality: The LIFE Study.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Impact of Heavy Metals on Human Male Fertility-An Overview.Antioxidants (Basel, Switzerland) · 2021Review
- Hair mercury levels, intake of omega-3 fatty acids and ovarian reserve among women attending a fertility center.International journal of hygiene and environmental health · 2021Article
- Trends in time-to-pregnancy in the USA: 2002 to 2017.Human reproduction (Oxford, England) · 2021Article
- Fecundability and Sterility by Age: Estimates Using Time to Pregnancy Data of Japanese Couples Trying to Conceive Their First Child with and without Fertility Treatment.International journal of environmental research and public health · 2021Article
- Variability of essential and non-essential trace elements in the follicular fluid of women undergoing in vitro fertilization (IVF).Ecotoxicology and environmental safety · 2021Article
- Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF.Human reproduction open · 2021Article
- Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.Advances in pharmacology (San Diego, Calif.) · 2021Article
- Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals.Archives of toxicology · 2020Review
- The Association between Seafood Intake and Fecundability: Analysis from Two Prospective Studies.Nutrients · 2020Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The effect of heavy metals at environmentally relevant concentrations on couple fecundity has received limited study despite ubiquitous exposure. In 2005-2009, couples (n=501) desiring pregnancy and discontinuing contraception were recruited and asked to complete interviews and to provide blood specimens for the quantification of cadmium (μg L(-1)), lead (μg dL(-1)) and mercury (μg L(-1)) using inductively coupled plasma-mass spectrometry. Couples completed daily journals on lifestyle and intercourse along with menstruation and pregnancy testing for women. Couples were followed for 12 months or until pregnant. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated adjusting for age, body mass index, cotinine, and serum lipids in relation to female then male exposures. FORs <1 denote a longer time to pregnancy. In adjusted models, reduced FORs were observed for both female cadmium (0.78; 95% CI 0.63-0.97) and male lead (0.85; 95% CI 0.73-0.98) concentrations. When jointly modeling couples' exposures, only male lead concentration significantly reduced the FOR (0.82; 95% CI 0.68, 0.97), though the FOR remained <1 for female cadmium (0.80; 95% CI 0.64, 1.00). This prospective couple based cohort with longitudinal capture of time to pregnancy is suggestive of cadmium and lead's reproductive toxicity at environmentally relevant concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.