ArticleProceedings of the National Academy of Sciences of the United States of America2012
Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila.Cell discovery · 2023Article
- Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- The adipocyte-enriched secretory protein tetranectin exacerbates type 2 diabetes by inhibiting insulin secretion from β cells.Science advances · 2022Article
- Interorgan crosstalk in pancreatic islet function and pathology.FEBS letters · 2022Review
- RGS4-Deficiency Alters Intracellular Calcium and PKA-Mediated Control of Insulin Secretion in Glucose-Stimulated Beta Islets.Biomedicines · 2021Article
- Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour.Nature reviews. Endocrinology · 2021Review
- GPCRs, G Proteins, and Their Impact on β-cell Function.Comprehensive Physiology · 2020Review
- Physiological and Pathological Regulation of Peripheral Metabolism by Gut-Peptide Hormones inFrontiers in physiology · 2020Review
- Effects of Feeding-Related Peptides on Neuronal Oscillation in the Ventromedial Hypothalamus.Journal of clinical medicine · 2019Article
- GFrontiers in aging neuroscience · 2019Review
- Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.Epilepsia · 2018Article
- Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.Neurochemical research · 2017Article
- Low levels of plasma galanin in obese subjects with hypertension.Journal of endocrinological investigation · 2017Article
- Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function.Frontiers in endocrinology · 2017Review
- The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.Molecular metabolism · 2016Article
- Inter-organ communication and regulation of beta cell function.Diabetologia · 2016Review
- Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats.Journal of diabetes research · 2016Article
- There is Kisspeptin - And Then There is Kisspeptin.Trends in endocrinology and metabolism: TEM · 2015Review
- Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055.Neuropeptides · 2015Article
- Suppression of insulin production and secretion by a decretin hormone.Cell metabolism · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The neuropeptide galanin regulates numerous physiological activities in the body, including feeding and metabolism, learning and memory, nociception and spinal reflexes, and anxiety and related behaviors. Modulation of blood glucose levels by suppressing insulin release was the first reported activity for galanin. This inhibition was mediated by one or more pertussis toxin-sensitive G proteins of the G(i/o) subfamily. However, the molecular identities of the specific G protein(s) and intracellular effectors have not been fully revealed. Recently, we demonstrated that mice lacking G(o)2, but not other members of the G(i/o) protein family, secrete more insulin than controls upon glucose challenge, indicating that G(o)2 is a major transducer for the inhibitory regulation of insulin secretion. In this study, we investigated galanin signaling mechanisms in β cells using cell biological and electrophysiological approaches. We found that islets lacking G(o)2, but not other G(i/o) proteins, lose the inhibitory effect of galanin on insulin release. Potentiation of ATP-sensitive potassium (K(ATP)) and inhibition of calcium currents by galanin were disrupted by anti-G(o)2α antibodies. Galanin actions on K(ATP) and calcium currents were completely lost in G(o)2(-/-) β cells. Furthermore, the hyperglycemic effect of galanin is also blunted in G(o)2(-/-) mice. Our results demonstrate that G(o)2 mediates the inhibition of insulin release by galanin by regulating both K(ATP) and Ca(2+) channels in mice. Our findings provide insight into galanin's action in glucose homeostasis. The results may also be relevant to the understanding of galanin signaling in other biological systems, especially the central nervous system.
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