ArticleProceedings of the National Academy of Sciences of the United States of America2012
The diverse effects of mechanical loading on active hair bundles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- How Exceptional Is the Ear?Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- Auditory cellular cooperativity probed via spontaneous otoacoustic emissions.Biophysical journal · 2025Article
- Neural control and innate self-tuning of the hair cell's active process.Biophysical journal · 2024Article
- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- Complex dynamics of hair bundle of auditory nervous system (II): forced oscillations related to two cases of steady state.Cognitive neurodynamics · 2022Article
- Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea.Hearing research · 2022Article
- Complex dynamics of hair bundle of auditory nervous system (I): spontaneous oscillations and two cases of steady states.Cognitive neurodynamics · 2022Article
- Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.Biophysical journal · 2021Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- Bilateral Spontaneous Otoacoustic Emissions Show Coupling between Active Oscillators in the Two Ears.Biophysical journal · 2019Article
- A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.Trends in neurosciences · 2019Review
- Accelerated Age-Related Degradation of the Tectorial Membrane in theFrontiers in molecular neuroscience · 2019Article
- Design principles of hair-like structures as biological machines.Journal of the Royal Society, Interface · 2018Review
- Homeostatic enhancement of sensory transduction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Physiological Preparation of Hair Cells from the Sacculus of the American Bullfrog (Rana catesbeiana).Journal of visualized experiments : JoVE · 2017Article
- Electrophysiological Measurements of Peripheral Vestibular Function-A Review of Electrovestibulography.Frontiers in systems neuroscience · 2017Review
- High-order synchronization of hair cell bundles.Scientific reports · 2016Article
- Identification of Bifurcations from Observations of Noisy Biological Oscillators.Biophysical journal · 2016Article
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3 authors.
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Abstract
Hair cells in the auditory, vestibular, and lateral-line systems of vertebrates receive inputs through a remarkable variety of accessory structures that impose complex mechanical loads on the mechanoreceptive hair bundles. Although the physiological and morphological properties of the hair bundles in each organ are specialized for detecting the relevant inputs, we propose that the mechanical load on the bundles also adjusts their responsiveness to external signals. We use a parsimonious description of active hair-bundle motility to show how the mechanical environment can regulate a bundle's innate behavior and response to input. We find that an unloaded hair bundle can behave very differently from one subjected to a mechanical load. Depending on how it is loaded, a hair bundle can function as a switch, active oscillator, quiescent resonator, or low-pass filter. Moreover, a bundle displays a sharply tuned, nonlinear, and sensitive response for some loading conditions and an untuned or weakly tuned, linear, and insensitive response under other circumstances. Our simple characterization of active hair-bundle motility explains qualitatively most of the observed features of bundle motion from different organs and organisms. The predictions stemming from this description provide insight into the operation of hair bundles in a variety of contexts.
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