ArticleProceedings of the National Academy of Sciences of the United States of America2012
Control of target gene specificity during metamorphosis by the steroid response gene E93.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 80 citations in OpenAlex.
- Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes.International journal of molecular sciences · 2026Article
- Evolution of complete metamorphosis through temporal shifts in Chronologically inappropriate morphogenesis (Chinmo) and Broad.Development (Cambridge, England) · 2026Article
- E93 controls adult differentiation by repressingProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Stem cell-specific ecdysone signaling regulates the development of dorsal fan-shaped body neurons and sleep homeostasis.Current biology : CB · 2024Article
- Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila.Developmental cell · 2024Article
- Stem cell-specific ecdysone signaling regulates the development and function of abioRxiv : the preprint server for biology · 2023Article
- A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development.PLoS biology · 2023Article
- Increased chromatin accessibility promotes the evolution of a transcriptional silencer inScience advances · 2023Article
- Reduction of embryonicProceedings of the National Academy of Sciences of the United States of America · 2023Article
- CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito,The CRISPR journal · 2022Article
- Knockdown ofBiology · 2022Article
- Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.Developmental biology · 2022Article
- Pupal Diapause Termination and Transcriptional Response ofFrontiers in physiology · 2022Article
- Olfactory receptor-dependent receptor repression inScience advances · 2021Article
- E93 confers steroid hormone responsiveness of digestive enzymes to promote blood meal digestion in the midgut of the mosquito Aedes aegypti.Insect biochemistry and molecular biology · 2021Article
- Large-Scale Annotation and Evolution Analysis of MiRNA in Insects.Genome biology and evolution · 2021Article
- Mechanisms underlying the control of dynamic regulatory element activity and chromatin accessibility during metamorphosis.Current opinion in insect science · 2021Review
- RNAi-Mediated Knockdown of Transcription Factor E93 in Nymphs of the Desert Locust (International journal of molecular sciences · 2020Article
- The effect of E93 knockdown on female reproduction in the red flour beetle, Tribolium castaneum.Archives of insect biochemistry and physiology · 2020Article
- Developmental stage-specific distribution and phosphorylation of Mblk-1, a transcription factor involved in ecdysteroid-signaling in the honey bee brain.Scientific reports · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Hormonal control of sexual maturation is a common feature in animal development. A particularly dramatic example is the metamorphosis of insects, in which pulses of the steroid hormone ecdysone drive the wholesale transformation of the larva into an adult. The mechanisms responsible for this transformation are not well understood. Work in Drosophila indicates that the larval and adult forms are patterned by the same underlying sets of developmental regulators, but it is not understood how the same regulators pattern two distinct forms. Recent studies indicate that this ability is facilitated by a global change in the responsiveness of target genes during metamorphosis. Here we show that this shift is controlled in part by the ecdysone-induced transcription factor E93. Although long considered a dedicated regulator of larval cell death, we find that E93 is expressed widely in adult cells at the pupal stage and is required for many patterning processes at this time. To understand the role of E93 in adult patterning, we focused on a simple E93-dependent process, the induction of the Dll gene within bract cells of the pupal leg by EGF receptor signaling. In this system, we show that E93 functions to cause Dll to become responsive to EGF receptor signaling. We demonstrate that E93 is both necessary and sufficient for directing this switch. E93 likely controls the responsiveness of many other target genes because it is required broadly for patterning during metamorphosis. The wide conservation of E93 orthologs suggests that similar mechanisms control life-cycle transitions in other organisms, including vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.