ArticleProceedings of the National Academy of Sciences of the United States of America2012
Differential modulation of the default mode network via serotonin-1A receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- An individual patient data meta-analysis on vagal nerve stimulation for recovery from disorders of consciousness.Scientific reports · 2026Pooled it
- Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis.Molecular psychiatry · 2025Pooled it
- Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Atomoxetine Treatment Strengthens an Anti-Correlated Relationship between Functional Brain Networks in Medication-Naïve Adults with Attention-Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-Controlled Clinical Trial.The international journal of neuropsychopharmacology · 2015Trial
- Antidepressants normalize the default mode network in patients with dysthymia.JAMA psychiatry · 2013Trial
- Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography.European journal of nuclear medicine and molecular imaging · 2025Review
- Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments.bioRxiv : the preprint server for biology · 2025Article
- Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain.Brain structure & function · 2025Article
- The potential of 5-methoxy-N,N-dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action.Addiction biology · 2024Review
- Neural signatures of default mode network subsystems in first-episode, drug-naive patients with major depressive disorder after 6-week thought induction psychotherapy treatment.Brain communications · 2024Article
- The involvement of serotonin in major depression: nescience in disguise?Molecular psychiatry · 2024Article
- Efficacy of cranial electrotherapy stimulation in patients with burning mouth syndrome: a randomized, controlled, double-blind pilot study.Frontiers in neurology · 2024Article
- Transcriptomic Analysis of Glycosylation and Neuroregulatory Pathways in Rodent Models in Response to Psychedelic Molecules.International journal of molecular sciences · 2023Article
- Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Peripheral Interleukin-18 is negatively correlated with abnormal brain activity in patients with depression: a resting-state fMRI study.BMC psychiatry · 2022Article
- Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Neural correlates of product attachment to cosmetics.Scientific reports · 2021Article
- Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.Translational psychiatry · 2021Article
- Physiological changes in sleep that affect fMRI inference.Current opinion in behavioral sciences · 2020Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reflecting one's mental self is a fundamental process for evaluating the personal relevance of life events and for moral decision making and future envisioning. Although the corresponding network has been receiving growing attention, the driving neurochemical mechanisms of the default mode network (DMN) remain unknown. Here we combined positron emission tomography and functional magnetic resonance imaging to investigate modulations of the DMN via serotonin-1A receptors (5-HT(1A)), separated for 5-HT autoinhibition (dorsal raphe nucleus) and local inhibition (heteroreceptors in projection areas). Using two independent approaches, regional 5-HT(1A) binding consistently predicted DMN activity in the retrosplenial cortex for resting-state functional magnetic resonance imaging and the Tower of London task. On the other hand, both local and autoinhibitory 5-HT(1A) binding inversely modulated the posterior cingulate cortex, the strongest hub in the resting human brain. In the frontal part of the DMN, a negative association was found between the dorsal medial prefrontal cortex and local 5-HT(1A) inhibition. Our results indicate a modulation of key areas involved in self-referential processing by serotonergic neurotransmission, whereas variations in 5-HT(1A) binding explained a considerable amount of the individual variability in the DMN. Moreover, the brain regions associated with distinct introspective functions seem to be specifically regulated by the different 5-HT(1A) binding sites. Together with previously reported modulations of dopamine and GABA, this regional specialization suggests complex interactions of several neurotransmitters driving the default mode network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.