ArticleProceedings of the National Academy of Sciences of the United States of America2012
Subcellular calcium dynamics in a whole-cell model of an atrial myocyte.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Recombinant-Chemosynthetic Biosensors for Probing Cell Surface Signaling of Red Blood Cells and Other Cells.Chemical & biomedical imaging · 2025Article
- Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024Article
- A Stochastic Spatiotemporal Model of Rat Ventricular Myocyte Calcium Dynamics Demonstrated Necessary Features for Calcium Wave Propagation.Membranes · 2021Article
- Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.Frontiers in physiology · 2021Review
- Afterdepolarizations and abnormal calcium handling in atrial myocytes with modulated SERCA uptake: a sensitivity analysis of calcium handling channels.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- A Novel Computational Model of the Rabbit Atrial Cardiomyocyte With Spatial Calcium Dynamics.Frontiers in physiology · 2020Article
- Delayed afterdepolarization-induced triggered activity in cardiac purkinje cells mediated through cytosolic calcium diffusion waves.Physiological reports · 2019Article
- Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.JCI insight · 2019Article
- Axial Tubule Junctions Activate Atrial CaFrontiers in physiology · 2018Article
- Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale.Frontiers in physiology · 2018Article
- Mechanism for Triggered Waves in Atrial Myocytes.Biophysical journal · 2017Article
- Mechano-chemo-transduction in cardiac myocytes.The Journal of physiology · 2017Review
- Regional distribution of T-tubule density in left and right atria in dogs.Heart rhythm · 2017Article
- Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into CaClinical Medicine Insights. Cardiology · 2017Article
- Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias.The Journal of biological chemistry · 2016Article
- Calcium is not required for triggering volume restoration in hypotonically challenged A549 epithelial cells.Pflugers Archiv : European journal of physiology · 2016Article
- Axial tubule junctions control rapid calcium signaling in atria.The Journal of clinical investigation · 2016Article
- Second Messengers.Cold Spring Harbor perspectives in biology · 2016Review
- Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.The Journal of physiology · 2016Review
- Role of Cytosolic Calcium Diffusion in Murine Cardiac Purkinje Cells.Clinical Medicine Insights. Cardiology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In this study, we present an innovative mathematical modeling approach that allows detailed characterization of Ca(2+) movement within the three-dimensional volume of an atrial myocyte. Essential aspects of the model are the geometrically realistic representation of Ca(2+) release sites and physiological Ca(2+) flux parameters, coupled with a computationally inexpensive framework. By translating nonlinear Ca(2+) excitability into threshold dynamics, we avoid the computationally demanding time stepping of the partial differential equations that are often used to model Ca(2+) transport. Our approach successfully reproduces key features of atrial myocyte Ca(2+) signaling observed using confocal imaging. In particular, the model displays the centripetal Ca(2+) waves that occur within atrial myocytes during excitation-contraction coupling, and the effect of positive inotropic stimulation on the spatial profile of the Ca(2+) signals. Beyond this validation of the model, our simulation reveals unexpected observations about the spread of Ca(2+) within an atrial myocyte. In particular, the model describes the movement of Ca(2+) between ryanodine receptor clusters within a specific z disk of an atrial myocyte. Furthermore, we demonstrate that altering the strength of Ca(2+) release, ryanodine receptor refractoriness, the magnitude of initiating stimulus, or the introduction of stochastic Ca(2+) channel activity can cause the nucleation of proarrhythmic traveling Ca(2+) waves. The model provides clinically relevant insights into the initiation and propagation of subcellular Ca(2+) signals that are currently beyond the scope of imaging technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.