ArticleProceedings of the National Academy of Sciences of the United States of America2012
Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 92 citations in OpenAlex.
- A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sleep function: an evolutionary perspective.The Lancet. Neurology · 2022Review
- Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands.PLoS biology · 2022Article
- Genome-wide association study of idiopathic hypersomnia in a Japanese population.Sleep and biological rhythms · 2022Article
- Expression of theJournal of neurogenetics · 2021Article
- TheJournal of neurogenetics · 2021Article
- A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.G3 (Bethesda, Md.) · 2021Article
- Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior.PLoS biology · 2021Article
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
- A sleep-like state inScience advances · 2020Article
- Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila.PLoS biology · 2020Article
- Sleep restores place learning to the adenylyl cyclase mutantJournal of neurogenetics · 2020Article
- Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity.PLoS genetics · 2020Article
- Genome-Wide Association Analysis of Anoxia Tolerance inG3 (Bethesda, Md.) · 2019Article
- Article
- Sleep inFrontiers in physiology · 2019Review
- Sleep regulates visual selective attention inThe Journal of experimental biology · 2018Article
- Article
- The adult foraging assay (AFA) detects strain and food-deprivation effects in feeding-related traits of Drosophila melanogaster.Journal of insect physiology · 2018Article
- The Sleep in Caenorhabditis elegans: What We Know Until Now.Molecular neurobiology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent human studies suggest that genetic polymorphisms allow an individual to maintain optimal cognitive functioning during sleep deprivation. If such polymorphisms were not associated with additional costs, selective pressures would allow these alleles to spread through the population such that an evolutionary alternative to sleep would emerge. To determine whether there are indeed costs associated with resiliency to sleep loss, we challenged natural allelic variants of the foraging gene (for) with either sleep deprivation or starvation. Flies with high levels of Protein Kinase G (PKG) (for(R)) do not display deficits in short-term memory following 12 h of sleep deprivation. However, short-term memory is significantly disrupted when for(R) flies are starved overnight. In contrast, flies with low levels of PKG (for(s), for(s2)) show substantial deficits in short-term memory following sleep deprivation but retain their ability to learn after 12 h of starvation. We found that for(R) phenotypes could be largely recapitulated in for(s) flies by selectively increasing the level of PKG in the α/β lobes of the mushroom bodies, a structure known to regulate both sleep and memory. Together, these data indicate that whereas the expression of for may appear to provide resilience in one environmental context, it may confer an unexpected vulnerability in other situations. Understanding how these tradeoffs confer resilience or vulnerability to specific environmental challenges may provide additional clues as to why an evolutionary alternative to sleep has not emerged.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.