ArticleProceedings of the National Academy of Sciences of the United States of America2012
Extensive X-linked adaptive evolution in central chimpanzees.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 91 citations in OpenAlex.
- Local genetic adaptation to habitat in wild chimpanzees.Science (New York, N.Y.) · 2025Article
- Genome-scale evolution in local populations of wild chimpanzees.Scientific reports · 2025Article
- Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Chromosome-scale genome of the polyphagous pest Anastrepha ludens (Diptera: Tephritidae) provides insights on sex chromosome evolution in Anastrepha.G3 (Bethesda, Md.) · 2024Article
- Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024Article
- Comparative Population Transcriptomics Provide New Insight into the Evolutionary History and Adaptive Potential of World Ocean Krill.Molecular biology and evolution · 2023Article
- Quantifying the fraction of new mutations that are recessive lethal.Evolution; international journal of organic evolution · 2023Article
- Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model.Molecular biology and evolution · 2022Article
- Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice andGenome research · 2021Article
- Urine as a high-quality source of host genomic DNA from wild populations.Molecular ecology resources · 2021Article
- A Study of Faster-Z Evolution in the Great Tit (Parus major).Genome biology and evolution · 2020Article
- Adaptive Evolution Patterns in the Pacific Oyster Crassostrea gigas.Marine biotechnology (New York, N.Y.) · 2019Article
- The Impact of Protein Architecture on Adaptive Evolution.Molecular biology and evolution · 2019Article
- Evidence for Faster X Chromosome Evolution in Spiders.Molecular biology and evolution · 2019Article
- Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells.Molecular biology and evolution · 2019Article
- Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
- Disentangling the Causes for Faster-X Evolution in Aphids.Genome biology and evolution · 2018Article
- Sequence and Structural Diversity of Mouse Y Chromosomes.Molecular biology and evolution · 2017Article
- Inference of Distribution of Fitness Effects and Proportion of Adaptive Substitutions from Polymorphism Data.Genetics · 2017Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surveying genome-wide coding variation within and among species gives unprecedented power to study the genetics of adaptation, in particular the proportion of amino acid substitutions fixed by positive selection. Additionally, contrasting the autosomes and the X chromosome holds information on the dominance of beneficial (adaptive) and deleterious mutations. Here we capture and sequence the complete exomes of 12 chimpanzees and present the largest set of protein-coding polymorphism to date. We report extensive adaptive evolution specifically targeting the X chromosome of chimpanzees with as much as 30% of all amino acid replacements being adaptive. Adaptive evolution is barely detectable on the autosomes except for a few striking cases of recent selective sweeps associated with immunity gene clusters. We also find much stronger purifying selection than observed in humans, and in contrast to humans, we find that purifying selection is stronger on the X chromosome than on the autosomes in chimpanzees. We therefore conclude that most adaptive mutations are recessive. We also document dramatically reduced synonymous diversity in the chimpanzee X chromosome relative to autosomes and stronger purifying selection than for the human X chromosome. If similar processes were operating in the human-chimpanzee ancestor as in central chimpanzees today, our results therefore provide an explanation for the much-discussed reduction in the human-chimpanzee divergence at the X chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.