Trial reportStroke2012
Ischemic transient neurological events identified by immune response to cerebral ischemia.
Trial report in Stroke, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02014896 (Ischemia Care Biomarkers of Acute Stroke Etiology), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- MicroRNAs as Potential Biomarkers and Therapeutic Targets in Ischemic Stroke from the Perspective of Inflammation.Current neuropharmacology · 2026Review
- Bioinformatics Identification of angiogenesis-related biomarkers and therapeutic targets in cerebral ischemia-reperfusion.Scientific reports · 2024Article
- Biomarkers for Transient Ischemic Attack: A Brief Perspective of Current Reports and Future Horizons.Journal of clinical medicine · 2022Review
- Modifications of gene expression detected in peripheral blood after brain ischemia treated with remote postconditioning.Molecular biology reports · 2022Article
- Acute Stroke Biomarkers: Are We There Yet?Frontiers in neurology · 2021Review
- Identification of Candidate Blood mRNA Biomarkers in Intracerebral Hemorrhage Using Integrated Microarray and Weighted Gene Co-expression Network Analysis.Frontiers in genetics · 2021Article
- Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.Nature reviews. Neurology · 2020Review
- PEGylated Erythropoietin Protects against Brain Injury in the MCAO-Induced Stroke Model by Blocking NF-κB Activation.Biomolecules & therapeutics · 2020Article
- Blood Biomarkers for Stroke Diagnosis and Management.Neuromolecular medicine · 2019Review
- Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression.Annals of clinical and translational neurology · 2019Article
- [Collateral circulation and Toll-like receptor 4 levels in patients with acute cerebral infarction after intravenous thrombolysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack.Brain : a journal of neurology · 2017Article
- Gene expression profiling in stroke: relevance of blood-brain interaction.Current opinion in pharmacology · 2016Review
- A new role for downstream Toll-like receptor signaling in mediating immediate early gene expression during focal cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets.PloS one · 2014Article
- All's well that transcribes well: non-coding RNAs and post-stroke brain damage.Neurochemistry international · 2013Review
- RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke.Annals of neurology · 2013Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeDeciphering whether a transient neurological event (TNE) is of ischemic or nonischemic etiology can be challenging. Ischemia of cerebral tissue elicits an immune response in stroke and transient ischemic attack (TIA). This response, as detected by RNA expressed in immune cells, could potentially distinguish ischemic from nonischemic TNE.
methodsAnalysis of 208 TIAs, ischemic strokes, controls, and TNE was performed. RNA from blood was processed on microarrays. TIAs (n=26) and ischemic strokes (n=94) were compared with controls (n=44) to identify differentially expressed genes (false discovery rate <0.05, fold change ≥1.2). Genes common to TIA and stroke were used predict ischemia in TIA diffusion-weighted imaging-positive/minor stroke (n=17), nonischemic TNE (n=13), and TNE of unclear etiology (n=14).
resultsSeventy-four genes expressed in TIA were common to those in ischemic stroke. Functional pathways common to TIA and stroke related to activation of innate and adaptive immune systems, involving granulocytes and B cells. A prediction model using 26 of the 74 ischemia genes distinguished TIA and stroke subjects from control subjects with 89% sensitivity and specificity. In the validation cohort, 17 of 17 TIA diffusion-weighted imaging-positive/minor strokes were predicted to be ischemic, and 10 of 13 nonischemic TNE were predicted to be nonischemic. In TNE of unclear etiology, 71% were predicted to be ischemic. These subjects had higher ABCD(2) scores.
conclusionsA common molecular response to ischemia in TIA and stroke was identified, relating to activation of innate and adaptive immune systems. TNE of ischemic etiology was identified based on gene profiles that may be of clinical use once validated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.