ArticleHepatitis monthly2011
Frequency of Two Common HFE Gene Mutations (C282Y and H63D) in a Group of Iranian Patients With Cryptogenic Cirrhosis.
Article in Hepatitis monthly, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- The Correlation of Cardiac and Hepatic Hemosiderosis as Measured by T2*MRI Technique with Ferritin Levels and Hemochromatosis Gene Mutations in Iranian Patients with Beta Thalassemia Major.Oman medical journal · 2018Article
- Frequency of Hereditary Hemochromatosis (HFE) Gene Mutations in Egyptian Beta Thalassemia Patients and its Relation to Iron Overload.Open access Macedonian journal of medical sciences · 2016Article
- Iranian hereditary hemochromatosis patients: baseline characteristics, laboratory data and gene mutations.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- HFE Gene Mutations, Iron Overload and Cryptogenic Liver Cirrhosis.Hepatitis monthly · 2012Article
- Association of HFE Gene Mutations With Liver Cirrhosis Depends on Induction of Iron Homeostasis Disturbances.Hepatitis monthly · 2012Article
- Iron overload and HFE mutations: are they relevant in cryptogenic cirrhosis?Hepatitis monthly · 2012Article
- HFE Gene Mutations in Cryptogenic Cirrhosis Patients.Hepatitis monthly · 2012Article
- Author's Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis.Hepatitis monthly · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human HFE gene (a key component of iron homeostasis in humans) is involved in hereditary hemochromatosis, a common autosomal recessive genetic disorder that is characterized by excessive intestinal iron absorption and progressive iron overload.
objectivesIn this study, we assessed the frequency of two common forms of hemochromatosis HFE gene mutation (C282Y and H63D) in patients suffering from cryptogenic cirrhosis. PATIENTS AND
methodsOne hundred and fifty individuals were included in this study, in which 100 were patients with cryptogenic cirrhosis and 50 were from the normal population. All individuals were examined for common HFE gene mutations by amplification of nucleotide 845 C282Y and 187 H63D alleles and product analysis using the polymerase chain reaction method and restriction enzyme digestion.
resultsNo case of either a homozygous or heterozygous C282Y mutation was found. For the H63D mutation, no homozygosity was detected but heterozygosity was detected in 22% of patients and in 28% of the normal population.
conclusionsHereditary hemochromatosis is not a major cause of cryptogenic cirrhosis in the Iranian population.
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