ArticleArteriosclerosis, thrombosis, and vascular biology2012
Intravascular optical coherence tomography detection of atherosclerosis and inflammation in murine aorta.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Serial Molecular-Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Increased macrophage activity in coronary plaques in patients with acute coronary syndrome and familial hypercholesterolemia.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Thin-cap fibroatheroma association with local inflammatory activity in coronary disease: an optical-coherence tomography study.Einstein (Sao Paulo, Brazil) · 2025Article
- Inflammatory Phenotype by OCT Coronary Imaging: Specific Features Among De Novo Lesions, In-Stent Neointima, and In-Stent Neo-Atherosclerosis.Arquivos brasileiros de cardiologia · 2022Article
- In vivo optical molecular imaging of inflammation and immunity.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease.Practical laboratory medicine · 2021Article
- Article
- Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use.Light, science & applications · 2020Article
- Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study.Heart and vessels · 2019Article
- Eicosapentaenoic acid therapy is associated with decreased coronary plaque instability assessed using optical frequency domain imaging.Clinical cardiology · 2019Article
- Impaired Cholesterol-Uptake Capacity of HDL Might Promote Target-Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation.Journal of the American Heart Association · 2019Observational
- Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study.Journal of the American Heart Association · 2017Article
- Clinical Characteristics and Prognosis of Peri-strut Low-intensity Area Detected by Optical Coherence Tomography.Chinese medical journal · 2015Article
- Validating a bimodal intravascular ultrasound (IVUS) and near-infrared fluorescence (NIRF) catheter for atherosclerotic plaque detection in rabbits.Biomedical optics express · 2015Article
- Differences determined by optical coherence tomography volumetric analysis in non-culprit lesion morphology and inflammation in ST-segment elevation myocardial infarction and stable angina pectoris patients.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2015Article
- The basics of intravascular optical coherence tomography.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2015Review
- Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography.Journal of medical imaging (Bellingham, Wash.) · 2015Article
- Macrophages and intravascular OCT bright spots: a quantitative study.JACC. Cardiovascular imaging · 2015Article
- Identification of vessel wall degradation in ascending thoracic aortic aneurysms with OCT.Biomedical optics express · 2014Article
- Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.Stroke · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe goal of this study was to evaluate the feasibility of imaging the aorta of apolipoprotein E-deficient (ApoE(-/-)) mice for the detection of atherosclerosis and macrophages using optical coherence tomography (OCT) compared with histology. METHODS AND
resultsAtherosclerosis was induced by high-fat diet in 7-week-old ApoE(-/-) mice for 10 (n=7) and 22 (n=7) weeks. Nine-week-old ApoE(-/-) mice (n=7) fed a standard chow diet were used as controls. OCT images of a 10-mm descending aorta in situ were performed in 4 mice for each, and plaque and macrophages were determined at 0.5-mm intervals. Automated detection and quantification of macrophages were performed independently using a customized algorithm. Coregistered histological cross-sections were stained with hematoxylin-eosin, Mac-3, and von Kossa. Three mice in each group had en face OCT imaging to detect macrophages, which were compared with lipid-positive area with Sudan IV. OCT images were successfully acquired in all mice. OCT and histology were able to discriminate macrophages and plaque among the 3 groups and showed excellent correlation for (1) visual detection of plaque (r=0.98) and macrophages (r=0.93), (2) automated detection and quantification of macrophages by OCT versus Mac-3-positive area (r=0.92), and (3) en face OCT detection of macrophages versus Sudan IV-positive area (r=0.92).
conclusionsMurine intra-aortic OCT is feasible and shows excellent correlation with histology for detection of atherosclerotic plaque and macrophages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.