ArticleHepatology (Baltimore, Md.)2012
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.
Article in Hepatology (Baltimore, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis.Genome research · 2024Pooled it
- Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Natural variation suggests candidate genes underlyingbioRxiv : the preprint server for biology · 2025Article
- Comparative Analysis of Species-Specific Hepatocyte Function and Drug Effects in a Liver Microphysiological System PhysioMimix LC12 and 96-Well Plates.ACS pharmacology & translational science · 2025Article
- Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH.Nature communications · 2024Article
- Associations between one-carbon metabolism and valproic acid-induced liver dysfunction in epileptic patients.Frontiers in pharmacology · 2024Article
- The Status of Oxidative Stress in Patients with Alcohol Dependence: A Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- Model systems and organisms for addressing inter- and intra-species variability in risk assessment.Regulatory toxicology and pharmacology : RTP · 2022Review
- A mini-review of the rodent models for alcoholic liver disease: shortcomings, application, and future prospects.Toxicology research · 2021Review
- Changes in hepatic triglyceride content with the activation of ER stress and increased FGF21 secretion during pregnancy.Nutrition & metabolism · 2021Article
- Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Stress of Strains: Inbred Mice in Liver Research.Gene expression · 2018Article
- Alcoholic liver disease: Utility of animal models.World journal of gastroenterology · 2018Review
- Heritability of the aged glutathione phenotype is dependent on tissue of origin.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Alteration of Hepatic Gene Expression along with the Inherited Phenotype of Acquired Fatty Liver in Chicken.Genes · 2018Article
- Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights.Gene expression · 2018Review
- Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Review
- Genetic and epigenetic determinants of inter-individual variability in responses to toxicants.Current opinion in toxicology · 2017Article
- Using zebrafish to model liver diseases-Where do we stand?Current pathobiology reports · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
unlabelledAlcoholic liver injury is a major public health issue worldwide. Even though the major mechanisms of this disease have been established over the past decades, little is known about genetic susceptibility factors that may predispose individuals who abuse alcoholic beverages to liver damage and subsequent pathological conditions. We hypothesized that a panel of genetically diverse mouse strains may be used to examine the role of endoplasmic reticulum (ER) stress and one-carbon metabolism in the mechanism of interindividual variability in alcoholic liver injury. We administered alcohol (up to 27 mg/kg/d) in a high-fat diet using an intragastric intubation model for 28 days to male mice from 14 inbred strains (129S1/SvImJ, AKR/J, BALB/cJ, BALB/cByJ, BTBR T+tf/J, C3H/HeJ, C57BL/10J, DBA/2J, FVB/NJ, KK/HIJ, MOLF/EiJ, NZW/LacJ, PWD/PhJ, and WSB/EiJ). Profound interstrain differences (more than 3-fold) in alcohol-induced steatohepatitis were observed among the strains in spite of consistently high levels of urine alcohol that were monitored throughout the study. We found that ER stress genes were induced only in strains with the most liver injury. Liver glutathione and methyl donor levels were affected in all strains, albeit to a different degree. The most pronounced effects that were closely associated with the degree of liver injury were hyperhomocysteinemia and strain-dependent differences in expression patterns of one-carbon metabolism-related genes.
conclusionOur data demonstrate that strain differences in alcohol-induced liver injury and steatosis are striking and independent of alcohol exposure and the most severely affected strains exhibit major differences in the expression of ER stress markers and genes of one-carbon metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.