ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pediatric-type high-grade glioma of the spinal cord in the molecular era: institutional case series and updated systematic review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Pooled it
- Malignant Spinal Tumors.Advances in experimental medicine and biology · 2023Article
- Pediatric spinal cord diffuse midline glioma, H3 K27-altered with intracranial and spinal leptomeningeal spread: A case report.The neuroradiology journal · 2022Article
- Demographic and prognostic factors of optic nerve astrocytoma: a retrospective study of surveillance, epidemiology, and end results (SEER).BMC cancer · 2021Article
- Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review.Frontiers in oncology · 2020Article
- Spinal Cord Diffuse Midline Glioma in a 4-Year-Old Boy.Child neurology open · 2019Article
- Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study.Journal of neuro-oncology · 2018Article
- Article
- Rare case of conus medullaris glioblastoma multiforme in a teenager.Surgical neurology international · 2017Article
- Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival.Chinese journal of cancer · 2016Article
- Evaluating extent of resection in pediatric glioblastoma: a multiple propensity score-adjusted population-based analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Management of pediatric spinal cord astrocytomas: outcomes with adjuvant radiation.International journal of radiation oncology, biology, physics · 2013Article
- Paediatric spinal glioblastoma: case report and review of therapeutic strategies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePediatric spinal glioblastoma multiforme (GBM) is rare. Evidence-directed management relies on studies in which such cases are only a subset of a larger group. We reviewed cases of pediatric spinal GBM to assess outcomes and identify prognostic factors related to treatment.
methodsClinical presentations, radiologic findings, surgical variables, radio- and chemotherapeutic management, and outcomes of eight pathologically proven cases of pediatric spinal GBM were reviewed.
resultsMedian age was 10 years. All patients presented with motor deficits. Four had sensory symptoms. Average McCormick score at presentation was II. There were three cervical, one cervicothoracic, and four thoracic tumors. Five had cysts. Patients underwent gross total resection (GTR) (n = 4), subtotal resection (STR) (n = 3), or biopsy (n = 1). Four patients improved neurologically after surgery. One patient was lost to follow-up. Seven received both chemo- and radiotherapy. Average overall survival was 15 months. Average survival after STR and GTR were 12.6 and 19.2 months, respectively. In the GTR subset, the 18-month-old patient survived 30 months, while the other two (>10 years) survived an average of 13.75 months. This difference based on age was not seen in the STR subset. Patients survived an average of 17.5 and 10.5 months, respectively, with and without tumoral cysts. Patients with cervical tumors survived an average of 12.5 months, 18.7 months with thoracic tumors, and 11.5 months with a cervicothoracic tumor.
conclusionsTumor location, presence of a cyst, gross total resection, and younger age are possible predictors of prolonged survival. Radiotherapy and chemotherapy remain widely used.
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