ArticleMolecular and cellular biochemistry2012
Macrophages actively accumulate malonyldialdehyde-modified but not enzymatically oxidized low density lipoprotein.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- The Role of Natural Low Molecular Weight Dicarbonyls in Atherogenesis and Diabetogenesis.Reviews in cardiovascular medicine · 2024Review
- Clearance and Utilization of Dicarbonyl-Modified LDL in Monkeys and Humans.International journal of molecular sciences · 2023Article
- Malondialdehyde as an Important Key Factor of Molecular Mechanisms of Vascular Wall Damage under Heart Diseases Development.International journal of molecular sciences · 2022Review
- Blood Plasma Lipoproteids: Oxidizability and Participation in the Transport of Acylhydroperoxy-Derivatives of Phospholipids.Doklady. Biochemistry and biophysics · 2022Article
- Dicarbonyl-Dependent Modification of LDL as a Key Factor of Endothelial Dysfunction and Atherosclerotic Vascular Wall Damage.Antioxidants (Basel, Switzerland) · 2022Review
- Multiple rare and common variants in APOB gene locus associated with oxidatively modified low-density lipoprotein levels.PloS one · 2019Article
- Influence of dicarbonyls on kinetic characteristics of glutathione peroxidase.Doklady. Biochemistry and biophysics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we show that low density lipoproteins (LDL) from human blood plasma which was oxidized by animal C-15 lipoxygenase is taken up by cultivated human macrophages with the same effectiveness as with non-oxidized (native) LDL. At the same time malonyldialdehyde-modified LDL is captured by cultivated macrophages very actively. Based on differences in catabolism of LDL with various levels of primary and secondary products of free-radical oxidation, it was offered to discriminate between the oxidized LDL itself (lipohydroperoxide-rich LDL) and the LDL that was chemically modified by free-radical oxidation secondary products of aldehyde nature. In this respect, aldehyde-modified but not oxidized (lipohydroperoxide-containing) LDL is atherogenic.
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Registered trials
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