ArticleMolecular and cellular biochemistry2012
Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-β1/Smad pathway.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies.International journal of molecular sciences · 2022Pooled it
- SMAD2, SMAD3 and TGF-β GENE expressions in women suffering from urge urinary incontinence and pelvic organ prolapse.Molecular biology reports · 2021Trial
- A Cell-Based Therapeutic Strategy for Stress Urinary Incontinence: Functional and Molecular Evidence from Decidua-Derived Mesenchymal Stromal Cells.International journal of molecular sciences · 2026Article
- Association between SMAD3 and SMAD7 gene polymorphisms and susceptibility to stress urinary incontinence in Chinese women.American journal of translational research · 2025Article
- Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets.Molecular medicine (Cambridge, Mass.) · 2024Review
- The role of Gestational Diabetes Mellitus and pelvic floor 3D-ultrasound assessment during pregnancy predicting urinary incontinence: a prospective cohort study.BMC pregnancy and childbirth · 2023Article
- Advances in the molecular pathogenesis and cell therapy of stress urinary incontinence.Frontiers in cell and developmental biology · 2023Review
- Establishment of Rat Model of Female Genital Sexual Arousal Disorder.Sexual medicine · 2022Article
- Stress urinary incontinence and the forgotten female hormones.International urogynecology journal · 2022Article
- Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2020Article
- Effect of integrin β1 in the treatment of stress urinary incontinence by electrical stimulation.Molecular medicine reports · 2019Article
- Effects of multiple simulated birth traumas on urethral continence function in rats.American journal of physiology. Renal physiology · 2017Article
- Potential therapeutic role of punicalagin against mechanical-trauma-induced stress urinary incontinence via upregulation of Nrf2 and TGF-β1 signaling : Effect of punicalagin on mechanical trauma induced SUI.International urogynecology journal · 2017Article
- Mechanism of Mechanical Trauma-Induced Extracellular Matrix Remodeling of Fibroblasts in Association with Nrf2/ARE Signaling Suppression Mediating TGF-Oxidative medicine and cellular longevity · 2017Article
- Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics.Journal of cell science · 2016Article
- A mouse model of urofacial syndrome with dysfunctional urination.Human molecular genetics · 2015Article
- Evaluation of the relationship between the pelvic floor muscles and insulin resistance.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Article
- Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach.International urogynecology journal · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study pathological changes of fibromuscular system and the role of TGF-β1/Smad pathway in the urethra of a parturition-induced stress urinary incontinence (SUI) rat model. Twenty-eight 8-week-old Sprague-Dawley female rats at gestational day 16 were used and randomized into two groups: sham group and SUI group. After delivery, rats in the SUI group underwent postpartum vaginal balloon dilation and bilateral ovariectomy. 1 month after ovariectomy, urodynamics was assessed. Histological examination (Masson's trichrome stain, picrosirius red stain, Hart's elastin stain, Gordon & Sweet's stain, and immunohistochemical stain) and Western blot were performed on urethral tissues. Both leak point pressure and maximal bladder capacity were significantly decreased in the balloon-injured ovariectomized rats, compared with the sham rats. Muscle was significantly decreased in the urethra of SUI rats compare with sham rats. Collagen I/III and reticular fibers from SUI group were also significantly lower than sham group. Meanwhile, elastic fibers and reticular fibers showed fragmentation and disorganization indicating impairment in the fibromuscular system in SUI rats. TGF-β1, MMP-9, and phosphorylated Smad2 (p-Smad2) were expressed significantly higher in SUI than in sham rats. Simulated birth trauma and menopause induced an upregulation of the TGF-β1/Smad pathway and impairment of the fibromuscular system in the urethra.
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