ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Increased PAI-1 in females compared with males is protective for abdominal aortic aneurysm formation in a rodent model.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Cardiac Hemorrhage Precedes Hypertension-induced Fibrosis in Plasminogen Activator Inhibitor-1 Deficient Mice.bioRxiv : the preprint server for biology · 2025Article
- Sex-specific systemic metabolic predictors of resistance to calorie restriction-induced weight loss in obese diversity outbred mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Sexual Dimorphism in Abdominal Aortic Aneurysm-Insights from Clinical and Experimental Studies.Journal of vascular diseases · 2025Article
- Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Bioinformatics-based identification of lipid- and immune-related biomarkers in abdominal aortic aneurysms.Heliyon · 2023Article
- Peptide Amphiphile Supramolecular Nanofibers Designed to Target Abdominal Aortic Aneurysms.ACS nano · 2022Article
- Second Heart Field-Derived Cells Contribute to Angiotensin II-Mediated Ascending Aortopathies.Circulation · 2022Article
- Double-edged sword of diabetes mellitus for abdominal aortic aneurysm.Frontiers in endocrinology · 2022Review
- Identification of MEDAG and SERPINE1 Related to Hypoxia in Abdominal Aortic Aneurysm Based on Weighted Gene Coexpression Network Analysis.Frontiers in physiology · 2022Article
- Article
- Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.JVS-vascular science · 2021Review
- Female Mice Exhibit Abdominal Aortic Aneurysm Protection in an Established Rupture Model.The Journal of surgical research · 2020Article
- Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease.American journal of physiology. Heart and circulatory physiology · 2017Review
- A novel chronic advanced stage abdominal aortic aneurysm murine model.Journal of vascular surgery · 2017Article
- Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections.Current problems in surgery · 2017Review
- Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms.Journal of vascular surgery · 2015Article
- Increased 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model.Annals of surgery · 2015Article
- Dietary phytoestrogens inhibit experimental aneurysm formation in male mice.The Journal of surgical research · 2014Article
- Phosphorylation of AKT and abdominal aortic aneurysm formation.The American journal of pathology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
The serine proteases, along with their inhibitor plasmin activator inhibitor-1 (PAI-1), have been shown to play a role in abdominal aortic aneurysm (AAA) formation. The aim of this study is to determine if PAI-1 may be a protective factor for AAA formation and partially responsible for the gender difference observed in AAAs. Male and female wild-type (WT) C57BL/6 and PAI-1(-/-) mice 8-12 wk of age underwent aortic perfusion with porcine pancreatic elastase. Animals were harvested 14 days following perfusion and analyzed for phenotype, PAI-1 protein levels, and matrix metalloproteinase (MMP)-9 and -2 activity. WT males had an average increase in aortic diameter of 80%, whereas females only increased 32% (P < 0.001). PAI-1(-/-) males increased 204% and females 161%, significantly more than their WT counterparts (P < 0.001). Western blot revealed 61% higher PAI-1 protein levels in the WT females compared with the WT males (P = 0.01). Zymography revealed higher levels of pro-MMP-2 and active MMP-2 in the PAI-1(-/-) males and females compared with their WT counterparts. PAI-1(-/-) females had significantly higher serum plasmin levels compared with WT females (P = 0.003). In conclusion, WT female mice are protected from aneurysm formation and have higher levels of PAI-1 compared with males during experimental aneurysm formation. Additionally, both male and female PAI-1(-/-) animals develop significantly larger aneurysms than WT animals, correlating with higher pro- and active MMP-2 levels. These findings suggest that PAI-1 is protective for aneurysm formation in the elastase model of AAA and plays a role in the gender differences seen in AAA formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.