ArticleProceedings of the National Academy of Sciences of the United States of America2012
Noninvasive inference of the molecular chemotactic response using bacterial trajectories.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Article
- Sigma B regulated motility and chemotaxis inMicrobiology (Reading, England) · 2026Article
- ChemotaxingbioRxiv : the preprint server for biology · 2025Article
- ChemotaxingArXiv · 2025Article
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Statistical signature of subtle behavioral changes in large-scale assays.PLoS computational biology · 2025Article
- Coarse-graining bacterial diffusion in disordered media to surface states.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An internal expectation guidesScience advances · 2022Article
- Article
- Steady-state running rate sets the speed and accuracy of accumulation of swimming bacteria.Biophysical journal · 2022Article
- Escherichia coli chemotaxis is information limited.Nature physics · 2021Article
- Non-Genetic Diversity in Chemosensing and Chemotactic Behavior.International journal of molecular sciences · 2021Review
- Article
- Swimming Escherichia coli Cells Explore the Environment by Lévy Walk.Applied and environmental microbiology · 2021Article
- Chemotaxis strategies of bacteria with multiple run modes.Science advances · 2020Article
- Article
- Enhanced propagation of motile bacteria on surfaces due to forward scattering.Nature communications · 2019Article
- Multiple CheY Homologs Control Swimming Reversals and Transient Pauses in Azospirillum brasilense.Biophysical journal · 2019Article
- Bacterial chemotaxis in a microfluidic T-maze reveals strong phenotypic heterogeneity in chemotactic sensitivity.Nature communications · 2019Article
- Connecting single-cell properties to collective behavior in multiple wild isolates of the Enterobacter cloacae complex.PloS one · 2019Article
Corrections and comments
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5 authors.
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Abstract
The quality of sensing and response to external stimuli constitutes a basic element in the selective performance of living organisms. Here we consider the response of Escherichia coli to chemical stimuli. For moderate amplitudes, the bacterial response to generic profiles of sensed chemicals is reconstructed from its response function to an impulse, which then controls the efficiency of bacterial motility. We introduce a method for measuring the impulse response function based on coupling microfluidic experiments and inference methods: The response function is inferred using Bayesian methods from the observed trajectories of bacteria swimming in microfluidically controlled chemical fields. The notable advantages are that the method is based on the bacterial swimming response, it is noninvasive, without any genetic and/or mechanical preparation, and assays the behavior of the whole flagella bundle. We exploit the inference method to measure responses to aspartate and α-methylaspartate--measured previously by other methods--as well as glucose, leucine, and serine. The response to the attractant glucose is shown to be biphasic and perfectly adapted, as for aspartate. The response to the attractant serine is shown to be biphasic yet imperfectly adapted, that is, the response function has a nonzero (positive) integral. The adaptation of the response to the repellent leucine is also imperfect, with the sign of the two phases inverted with respect to serine. The diversity in the bacterial population of the response function and its dependency upon the background concentration are quantified.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.