ArticleProceedings of the National Academy of Sciences of the United States of America2012
Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- The making of the Drosophila mushroom body.Frontiers in physiology · 2023Review
- Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain.Journal of visualized experiments : JoVE · 2021Article
- Study on the Effect of Wing Bud Chitin Metabolism and Its Developmental Network Genes in the Brown Planthopper,Frontiers in physiology · 2017Article
- Expression of the Drosophila homeobox gene, Distal-less, supports an ancestral role in neural development.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Associating schizophrenia, long non-coding RNAs and neurostructural dynamics.Frontiers in molecular neuroscience · 2015Review
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Authors and funding
5 authors.
Funding
Abstract
Vertebrate Dlx genes have been implicated in the differentiation of multiple neuronal subtypes, including cortical GABAergic interneurons, and mutations in Dlx genes have been linked to clinical conditions such as epilepsy and autism. Here we show that the single Drosophila Dlx homolog, distal-less, is required both to specify chemosensory neurons and to regulate the morphologies of their axons and dendrites. We establish that distal-less is necessary for development of the mushroom body, a brain region that processes olfactory information. These are important examples of distal-less function in an invertebrate nervous system and demonstrate that the Drosophila larval olfactory system is a powerful model in which to understand distal-less functions during neurogenesis.
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