ArticleProceedings of the National Academy of Sciences of the United States of America2012
Transcriptional interpretation of the EGF receptor signaling gradient.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Stochastic phenotypes in RAS-dependent developmental diseases.Current biology : CB · 2023Article
- Shared cis-regulatory modules control expression of the tandem paralogs midline and H15 in the follicular epithelium.Development (Cambridge, England) · 2022Article
- A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization.Integrative and comparative biology · 2022Article
- The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.Development (Cambridge, England) · 2020Article
- Article
- Two Drosophilids exhibit distinct EGF pathway patterns in oogenesis.Development genes and evolution · 2018Article
- Simple Expression Domains Are Regulated by Discrete CRMs DuringG3 (Bethesda, Md.) · 2017Article
- Gene regulation duringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Complex structures from patterned cell sheets.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.PLoS genetics · 2017Article
- Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary.Developmental biology · 2016Article
- BMP-dependent gene repression cascade in Drosophila eggshell patterning.Developmental biology · 2015Article
- Analysis of Cell Cycle Switches in Drosophila Oogenesis.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Regulation of broad by the Notch pathway affects timing of follicle cell development.Developmental biology · 2014Article
- A discrete model of Drosophila eggshell patterning reveals cell-autonomous and juxtacrine effects.PLoS computational biology · 2014Article
- Chorion patterning: a window into gene regulation and Drosophila species' relatedness.Molecular biology and evolution · 2014Article
- Optimized RNA ISH, RNA FISH and protein-RNA double labeling (IF/FISH) in Drosophila ovaries.Nature protocols · 2013Article
- Dynamic model for the coordination of two enhancers of broad by EGFR signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.Developmental biology · 2013Article
- Co-option of a coordinate system defined by the EGFr and Dpp pathways in the evolution of a morphological novelty.EvoDevo · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidermal growth factor receptor (EGFR) controls a wide range of developmental events, from body axes specification in insects to cardiac development in humans. During Drosophila oogenesis, a gradient of EGFR activation patterns the follicular epithelium. Multiple transcriptional targets of EGFR in this tissue have been identified, but their regulatory elements are essentially unknown. We report the regulatory elements of broad (br) and pipe (pip), two important targets of EGFR signaling in Drosophila oogenesis. br is expressed in a complex pattern that prefigures the formation of respiratory eggshell appendages. We found that this pattern is generated by dynamic activities of two regulatory elements, which display different responses to Pointed, Capicua, and Mirror, transcription factors involved in the EGFR-mediated gene expression. One of these elements is active in a pattern similar to pip, a gene repressed by EGFR and essential for establishing the dorsoventral polarity of the embryo. We demonstrate that this similarity of expression depends on a common sequence motif that binds Mirror in vitro and is essential for transcriptional repression in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.