ArticleAnnals of botany2012
Accelerated evolution and coevolution drove the evolutionary history of AGPase sub-units during angiosperm radiation.
Article in Annals of botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Decreased Nitrogen and Carbohydrate Metabolism Activity Leads to Grain Yield Reduction in Qingke Under Continuous Cropping.Plants (Basel, Switzerland) · 2025Article
- Article
- Comparative Analysis of AGPase Genes and Encoded Proteins in Eight Monocots and Three Dicots with Emphasis on Wheat.Frontiers in plant science · 2017Article
- Lineage-Specific Evolutionary Histories and Regulation of Major Starch Metabolism Genes during Banana Ripening.Frontiers in plant science · 2016Article
- AGPase: its role in crop productivity with emphasis on heat tolerance in cereals.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Review
- Adaptive evolution and divergent expression of heat stress transcription factors in grasses.BMC evolutionary biology · 2014Article
- Molecular evolution accompanying functional divergence of duplicated genes along the plant starch biosynthesis pathway.BMC evolutionary biology · 2014Article
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5 authors.
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Abstract
BACKGROUND AND
aimsADP-glucose pyrophosphorylase (AGPase) is a key enzyme of starch biosynthesis. In the green plant lineage, it is composed of two large (LSU) and two small (SSU) sub-units encoded by paralogous genes, as a consequence of several rounds of duplication. First, our aim was to detect specific patterns of molecular evolution following duplication events and the divergence between monocotyledons and dicotyledons. Secondly, we investigated coevolution between amino acids both within and between sub-units.
methodsA phylogeny of each AGPase sub-unit was built using all gymnosperm and angiosperm sequences available in databases. Accelerated evolution along specific branches was tested using the ratio of the non-synonymous to the synonymous substitution rate. Coevolution between amino acids was investigated taking into account compensatory changes between co-substitutions. KEY
resultsWe showed that SSU paralogues evolved under high functional constraints during angiosperm radiation, with a significant level of coevolution between amino acids that participate in SSU major functions. In contrast, in the LSU paralogues, we identified residues under positive selection (1) following the first LSU duplication that gave rise to two paralogues mainly expressed in angiosperm source and sink tissues, respectively; and (2) following the emergence of grass-specific paralogues expressed in the endosperm. Finally, we found coevolution between residues that belong to the interaction domains of both sub-units.
conclusionsOur results support the view that coevolution among amino acid residues, especially those lying in the interaction domain of each sub-unit, played an important role in AGPase evolution. First, within SSU, coevolution allowed compensating mutations in a highly constrained context. Secondly, the LSU paralogues probably acquired tissue-specific expression and regulatory properties via the coevolution between sub-unit interacting domains. Finally, the pattern we observed during LSU evolution is consistent with repeated sub-functionalization under 'Escape from Adaptive Conflict', a model rarely illustrated in the literature.
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