ReviewCurrent psychiatry reports2012
Genetic variation in the epigenetic machinery and mental health.
Review in Current psychiatry reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Recent Advances in Searching for DNMT Inhibitors and Their Potential Application in Treating Human Diseases.International journal of molecular sciences · 2026Review
- Epigenetics, Resilience, Protective Factors and Factors Promoting Positive Outcomes: A Scoping Review.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders.Frontiers in genetics · 2022Article
- Single-Cell Transcriptomics Supports a Role ofInternational journal of molecular sciences · 2021Review
- Chromatin Remodeler CHD8 in Autism and Brain Development.Journal of clinical medicine · 2021Review
- Review
- Stressful Newborn Memories: Pre-Conceptual,Frontiers in psychiatry · 2019Review
- Chromatin Remodeling Complex NuRD in Neurodevelopment and Neurodevelopmental Disorders.Frontiers in genetics · 2019Review
- Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants.International journal of genomics · 2019Review
- Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Prenatal Alcohol Exposure Is Associated With Adverse Cognitive Effects and Distinct Whole-Genome DNA Methylation Patterns in Primary School Children.Frontiers in behavioral neuroscience · 2018Article
- How Accumulated Real Life Stress Experience and Cognitive Speed Interact on Decision-Making Processes.Frontiers in human neuroscience · 2017Article
- Impact of DNMT1 and DNMT3a forebrain knockout on depressive- and anxiety like behavior in mice.Neurobiology of learning and memory · 2016Article
- Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers.International journal of epidemiology · 2015Article
- Review
- Role of DNA methylation and the DNA methyltransferases in learning and memory.Dialogues in clinical neuroscience · 2014Review
- Transcriptional co-repressors and memory storage.Neuropharmacology · 2014Review
- The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.Psychoneuroendocrinology · 2013Review
- Understanding resilience.Frontiers in behavioral neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation and chromatin modifications regulate gene expression and contribute to changes in brain transcriptomes underlying neurodevelopmental and psychiatric disorders. Clinical genetics and preclinical animal models highlight the crucial importance of the correct establishment of epigenetic marks during sensitive windows of development for normal brain function. On the same side of the coin, some of the concerned factors also appear engaged in the programming of experience-dependent long-term effects on mental health following exposure to relevant early-life events. Delineating the particular role of genetic variations in these players could provide new insights into the molecular basis of vulnerability and resilience and advance tailored therapies.
Indexed as
Identifiers
22307409What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.