ArticlePediatric cardiology2012
The role of Shox2 in SAN development and function.
Article in Pediatric cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transcriptional profile of the rat cardiovascular system at single-cell resolution.Cell reports · 2025Article
- A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells.Signal transduction and targeted therapy · 2024Article
- The miR-17-92 cluster in cardiac health and disease.Birth defects research · 2024Review
- Transcriptional profile of the rat cardiovascular system at single cell resolution.bioRxiv : the preprint server for biology · 2023Article
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- Recombinant Adeno-Associated Viral Vector-Mediated Gene Transfer ofInternational journal of molecular sciences · 2022Article
- [SHOX2 promotes migration, invasion and stemness of bladder cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- PDGFRα-Signaling Is Dispensable for the Development of the Sinoatrial Node After Its Fate Commitment.Frontiers in cell and developmental biology · 2021Article
- Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes.Frontiers in genetics · 2021Article
- Detection of SHOX2 DNA methylation by methylation-specific PCR in non-small cell lung cancer.Translational cancer research · 2020Article
- Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1.Cardiovascular research · 2020Article
- Gene Therapy Approaches to Biological Pacemakers.Journal of cardiovascular development and disease · 2018Review
- Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.Basic research in cardiology · 2016Article
- Reprogramming the conduction system: Onward toward a biological pacemaker.Trends in cardiovascular medicine · 2016Review
- Promoter hypermethylation ofClinical epigenetics · 2016Article
- Diagnosis of Lung Cancer by SHOX2 Gene Methylation Assay.Molecular diagnosis & therapy · 2015Review
- Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Phosphorylation of Shox2 is required for its function to control sinoatrial node formation.Journal of the American Heart Association · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Embryonic development is a tightly regulated process, and many families of genes functions to provide a regulatory genetic network to achieve such a program. The homeobox genes are an extensive family that encodes transcription factors with a characteristic 60-amino acid homeodomain. Mutations in these genes or in the encoded proteins might result in structural malformations, physiological defects, and even embryonic death. Mutations in the short-stature homeobox gene (SHOX) is associated with idiopathic short stature in humans, as observed in patients with Turner syndrome and/or Leri-Weill dyschondrosteosis. A closely related human homolog, SHOX2, has not been linked to any syndrome or defect so far. In mice, a SHOX ortholog gene is not present in the genome; however, a true SHOX2 ortholog has been identified. Analyses of Shox2 knockout mouse models have showed crucial functions during embryonic development, including limb skeletogenesis, palatogenesis, temporomandibular joint formation, and cardiovascular development. During embryonic cardiac development, Shox2 is restrictedly expressed in the sinus venosus region, including the sinoatrial node (SAN) and the sinus valves. Shox2 null mutant is embryonically lethal due to cardiovascular defects, including a severely hypoplastic SAN and sinus valves attributed to a significantly decreased level of cell proliferation in addition to an abnormal low heartbeat rate (bradycardia). In addition, it has been demonstrated that Shox2 regulates a genetic network through the repression of Nkx2.5 to maintain the SAN fate and thus plays essential roles in its proper formation and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.