Evidence map›Paper›PMID 22306946›Full record

ArticleThe American journal of gastroenterology2012

Pancreas divisum does not cause pancreatitis, but associates with CFTR mutations.

Matthew J DiMagno, Eugene P Dimagno

Open access · greenAbstract readEditorialComment
In one paragraph

Article in The American journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Recurrent Acute Pancreatitis: Current Concepts in the Diagnosis and Management.Current treatment options in gastroenterology · 2018
    Review
  10. Review
  11. Acute Pancreatitis.The New England journal of medicine · 2016
    Review
  12. Article
  13. Article
  14. Drug induced acute pancreatitis: does it exist?World journal of gastroenterology · 2014
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Matthew J DiMagno
Eugene P Dimagno
Mayo Clinic · USUniversity of Michigan–Ann Arbor · US

Funding

Inflammatory response to pancreatitis in CF mice: sodium & impaired apoptosisK08DK073298 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIMAGNO, MATTHEW J · 2006 to 2010
$716k
Pioglitazone Therapy for Endocrine and Exocrine Disease in Alcoholic PancreatitisR21AA017271 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIMAGNO, MATTHEW J · 2008 to 2009
$406k
NIAAA NIH HHS R21 AA017271NIDDK NIH HHS K08 DK073298
6 · The paper itself

Abstract

Bertin et al. partially dispel arguments that pancreas divisum (PD) causes pancreatitis, but fascinatingly indicate that PD associates with CFTR gene mutations predisposing to pancreatitis. This association, however, does not definitely confer a pathophysiological role for PD in pancreatitis but may denote that PD co-mingles with CFTR mutations without influencing pancreatitis or CFTR mutations influence pancreatic duct embryogenesis. We advise "idiopathic pancreatitis" patients with PD to undergo genetic testing. In lieu of CFTR mutations undertake no endoscopic/surgical procedure; if CFTR mutations are found, then refer patients for genetic counseling and withhold endoscopic/surgical therapy unless randomized studies show benefit.

Indexed as

Carrier ProteinsCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansMalePancreasPancreatitisTrypsinTrypsin Inhibitor, Kazal PancreaticCarrier ProteinsCystic Fibrosis Transmembrane Conductance RegulatorPRSS1 protein, humanSPINK1 protein, humanTrypsinTrypsin Inhibitor, Kazal Pancreatic

Identifiers

PMID22306946
PMCPMC3458421
OpenAlexW1520767620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.