ArticleSurgery2012
Liver resection for liver metastases from nondigestive endocrine cancer: extrahepatic disease burden defines outcome.
Article in Surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-Term Outcomes After Hepatic and Pancreatic Resections for Metastases from Thyroid Cancer: a Systematic Review of the Literature.Journal of gastrointestinal cancer · 2019Pooled it
- Surgical resection of a liver metastasis from an ovarian granulosa cell tumor mimicking a simple hepatic cyst.Clinical journal of gastroenterology · 2026Article
- Liver metastasis of ovarian granulosa cell tumors: a case report and literature review.BMC women's health · 2026Review
- Article
- Right trisectionectomy for liver metastasis of granulosa cell tumor: a case report and literature review.Surgical case reports · 2020Article
- The added diagnostic value of complementary gadoxetic acid-enhanced MRI toCancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
- Optimizing therapy for radioactive iodine-refractory differentiated thyroid cancer: current state of the art and future directions.Minerva endocrinologica · 2012Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundFor patients with hepatic nondigestive endocrine metastases (HNEM), the role of liver resection is not well-defined.
methodsWe reviewed outcomes for patients who underwent liver resection for HNEM at 2 centers to identify predictors of survival.
resultsFrom 1991 to 2010, 51 patients underwent liver resection for HNEM. Primary tumor types were adrenal gland (n = 26), thyroid (n = 11), testicular germ cell (n = 9), and ovarian granulosa cell (n = 5). 28 patients (55%) had synchronous or early (diagnosed within 12 months after primary tumor resection) liver metastases. At liver resection, 26 patients (51%) had extrahepatic metastases, and 7 (14%) had ≥2 sites of extrahepatic metastases. 32 patients (63%) had major liver resection and 19 (37%) had a simultaneous extrahepatic procedure. 90-day postoperative morbidity and mortality rates were 27% and 2%, respectively. After median follow-up of 20 months (range, 1-144), the 5-year overall and recurrence-free survival rates were 58% and 37%, respectively. Survival was not affected by primary tumor type. In multivariate analysis, ≥2 sites of extrahepatic metastases (hazard ratio [HR] = 4.80; 95% confidence interval [CI] = 1.18-19.50; P = .028) and interval of ≤12 months between primary tumor resection and diagnosis of liver metastases (HR = 5.33; 95% CI = 1.11-25.71; P = .037) were associated with worse overall survival after liver resection.
conclusionFor selected patients, liver resection for HNEM is associated with long-term survival. The number of extrahepatic sites of metastasis and the timing of appearance of liver metastases should be considered in patient selection.
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