ArticleAmerican journal of epidemiology2012
Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.
Article in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.
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Who cites it
97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis.Molecular psychiatry · 2017Pooled it
- Implementation and reporting of causal mediation analysis in 2015: a systematic review in epidemiological studies.BMC research notes · 2016Pooled it
- Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility.Scientific reports · 2015Pooled it
- Quantitative assessment of the influence of common variations (rs8034191 and rs1051730) at 15q25 and lung cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association of glutathione S-transferase P1 gene polymorphism with the histological types of lung cancer: a meta-analysis.Molecular biology reports · 2013Pooled it
- Association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer.Molecular biology reports · 2012Pooled it
- Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.Annals of the American Thoracic Society · 2014Trial
- Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.Human genetics · 2013Trial
- ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifiesFrontiers in immunology · 2026Article
- Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.American journal of human genetics · 2025Article
- Birth weight, cardiovascular health, and the risk of cardiovascular disease: A longitudinal perspective from the UK biobank cohort.American journal of preventive cardiology · 2025Article
- Unraveling Causality: Innovations in Epidemiologic Methods.JMA journal · 2025Article
- Socioeconomic Status, Smoking, and Lung Cancer: Mediation and Bias Analysis in the SYNERGY Study.Epidemiology (Cambridge, Mass.) · 2025Article
- Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data.Annual review of statistics and its application · 2025Article
- Cardiovascular Health Score and Atherosclerotic Cardiovascular Disease in the Million Veteran Program.JAMA network open · 2024Article
- Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Chance, ignorance, and the paradoxes of cancer: Richard Peto on developing preventative strategies under uncertainty.European journal of epidemiology · 2023Article
- Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications.BMC medicine · 2023Article
- Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada.Scientific reports · 2023Article
- Methods for large-scale single mediator hypothesis testing: Possible choices and comparisons.Genetic epidemiology · 2023Review
37 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the risks of both lung cancer and nicotine dependence and associated smoking behavior. However, there remains debate as to whether the association with lung cancer is direct or is mediated by pathways related to smoking behavior. Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at Massachusetts General Hospital using 2 single nucleotide polymorphisms, rs8034191 and rs1051730, on 15q25.1. The results are validated using data from 3 other lung cancer studies. Tests for additive interaction (P = 2 × 10(-10) and P = 1 × 10(-9)) and multiplicative interaction (P = 0.01 and P = 0.01) were significant. Pooled analyses yielded a direct-effect odds ratio of 1.26 (95% confidence interval (CI): 1.19, 1.33; P = 2 × 10(-15)) for rs8034191 and an indirect-effect odds ratio of 1.01 (95% CI: 1.00, 1.01; P = 0.09); the proportion of increased risk mediated by smoking was 3.2%. For rs1051730, direct- and indirect-effect odds ratios were 1.26 (95% CI: 1.19, 1.33; P = 1 × 10(-15)) and 1.00 (95% CI: 0.99, 1.01; P = 0.22), respectively, with a proportion mediated of 2.3%. Adjustment for measurement error in smoking behavior allowing up to 75% measurement error increased the proportions mediated to 12.5% and 9.2%, respectively. These analyses indicate that the association of the variants with lung cancer operates primarily through other pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.