Evidence map›Paper›PMID 22306515›Full record

ReviewArchives of biochemistry and biophysics2012

Unconventional functions of microtubule motors.

Virgil Muresan, Zoia Muresan

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Non-transport functions of motor proteins in corticogenesis.Frontiers in cell and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Virgil MuresanDepartment of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA. muresavi@umdnj.edu
Zoia Muresan
Rutgers, The State University of New Jersey · US

Funding

Molecular Motors in Transport and Signaling by APPR01GM068596 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI MURESAN, VIRGIL · 2004 to 2009
$1.5M
Reporter Mice For APP Processing And TransportR21AG039668 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI MURESAN, ZOIA · 2011 to 2012
$352k
NIA NIH HHS AG039668NIA NIH HHS R21 AG039668NIGMS NIH HHS GM068596-05S1NIGMS NIH HHS R01 GM068596
6 · The paper itself

Abstract

With the functional characterization of proteins advancing at fast pace, the notion that one protein performs different functions - often with no relation to each other - emerges as a novel principle of how cells work. Molecular motors are no exception to this new development. Here, we provide an account on recent findings revealing that microtubule motors are multifunctional proteins that regulate many cellular processes, in addition to their main function in transport. Some of these functions rely on their motor activity, but others are independent of it. Of the first category, we focus on the role of microtubule motors in organelle biogenesis, and in the remodeling of the cytoskeleton, especially through the regulation of microtubule dynamics. Of the second category, we discuss the function of microtubule motors as static anchors of the cargo at the destination, and their participation in regulating signaling cascades by modulating interactions between signaling proteins, including transcription factors. We also review atypical forms of transport, such as the cytoplasmic streaming in the oocyte, and the movement of cargo by microtubule fluctuations. Our goal is to provide an overview of these unexpected functions of microtubule motors, and to incite future research in this expanding field.

Indexed as

Models, BiologicalModels, ChemicalAnimalsHumansMicrotubulesModels, MolecularMolecular Motor ProteinsStructure-Activity RelationshipMolecular Motor Proteins

Identifiers

PMID22306515
PMCPMC3307959
OpenAlexW2067791702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.