Evidence map›Paper›PMID 22306343›Full record

ArticleCancer letters2012

Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm.

Yu Wang, Yanjie Li, Depeng Wang, Yi Li, Abraham Chang, William K Chan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu WangDepartment of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA.
Yanjie Li
Depeng Wang
Yi Li
Abraham Chang
William K Chan
University of the Pacific · US

Funding

Studies on the Ah Receptors Signaling MechanismR01ES014050 · NIEHS · UNIVERSITY OF THE PACIFIC-STOCKTON · PI CHAN, WILLIAM K · 2006 to 2010
$1.2M
NIEHS NIH HHS R01 ES014050NIEHS NIH HHS R01ES014050
6 · The paper itself

Abstract

The aryl hydrocarbon receptor nuclear translocator (ARNT) heterodimerizes with hypoxia inducible factor-1α (HIF-1α), followed by upregulation of genes that are essential for carcinogenesis. We utilized a novel peptide (Ainp1) to address whether the HIF-1α signaling could be suppressed by an ARNT-mediated mechanism. Ainp1 suppresses the HIF-1α-dependent luciferase expression in Hep3B cells and this suppression can be reversed by ARNT. Ainp1 reduces the interaction between ARNT and HIF-1α, suppresses the formation of the HIF-1 gel shift complex, and suppresses the ARNT recruitment to the vegf promoter. These effects are partly mediated by redistribution of the nuclear ARNT contents to the cytoplasm.

Indexed as

Amino Acid SequenceAryl Hydrocarbon Receptor Nuclear TranslocatorBase SequenceCell Line, TumorCell NucleusCobaltCytoplasmHumansHypoxia-Inducible Factor 1, alpha SubunitImmunoprecipitationLiver NeoplasmsLuciferasesMolecular Sequence DataPromoter Regions, GeneticProtein MultimerizationTransfectionARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorCobaltcobaltous chlorideHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitLuciferasesVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID22306343
PMCPMC3319868
OpenAlexW2104643834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.