ArticleMolecular cell2012
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.
Article in Molecular cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 71 citations in OpenAlex.
- Evolution of the Cell-Cycle Clock Models: Biochemical or Transcriptional?Advances in experimental medicine and biology · 2026Review
- Stochastic Boolean model of normal and aberrant cell cycles in budding yeast.NPJ systems biology and applications · 2024Article
- The oscillation of mitotic kinase governs cell cycle latches in mammalian cells.Journal of cell science · 2024Article
- A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets.Mathematical biosciences · 2024Article
- Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle.Nature metabolism · 2023Article
- Genome-wide identification, evolutionary and expression analysis of the cyclin-dependent kinase gene family in peanut.BMC plant biology · 2023Article
- Repression of essential cell cycle genes increases cellular fitness.PLoS genetics · 2022Article
- Mitotic kinase oscillation governs the latching of cell cycle switches.Current biology : CB · 2022Article
- Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes.BMC bioinformatics · 2022Article
- Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast.NPJ systems biology and applications · 2021Review
- Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans.PLoS genetics · 2021Article
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- Peroxiredoxins couple metabolism and cell division in an ultradian cycle.Nature chemical biology · 2021Article
- CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene.Frontiers in oncology · 2021Review
- An intrinsic oscillator drives the blood stage cycle of the malaria parasiteScience (New York, N.Y.) · 2020Article
- Using extremal events to characterize noisy time series.Journal of mathematical biology · 2020Article
- The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.Cell cycle (Georgetown, Tex.) · 2019Article
- Quantitative Studies for Cell-Division Cycle Control.Frontiers in physiology · 2019Review
- Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae.Molecular biology of the cell · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex, incorporating multiple G1, S phase, and mitotic cyclin-CDK complexes. However, periodic events persist in yeast cells lacking all S phase and mitotic B-cyclin genes, challenging the assertion that cyclin-CDK complexes are essential for oscillations. These and other results led to the proposal that a network of sequentially activated transcription factors functions as an underlying cell-cycle oscillator. Here we examine the individual contributions of a transcription factor network and cyclin-CDKs to the maintenance of cell-cycle oscillations. Our findings suggest that while cyclin-CDKs are not required for oscillations, they do contribute to oscillation robustness. A model emerges in which cyclin expression (thereby, CDK activity) is entrained to an autonomous transcriptional oscillator. CDKs then modulate oscillator function and serve as effectors of the oscillator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.