ArticleEuropean journal of pharmacology2012
Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats.
Article in European journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Effects of methylphenidate on quantitative measures of motor function: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Consequences of Acute or Chronic Methylphenidate Exposure Using Ex Vivo Neurochemistry and In Vivo Electrophysiology in the Prefrontal Cortex and Striatum of Rats.International journal of molecular sciences · 2022Article
- Comparison of the VTA and LC response to methylphenidate: a concomitant behavioral and neuronal study of adolescent male rats.Journal of neurophysiology · 2017Article
- D1 and D2 specific dopamine antagonist modulate the caudate nucleus neuronal responses to chronic methylphenidate exposure.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Caudate neuronal recording in freely behaving animals following acute and chronic dose response methylphenidate exposure.Pharmacology, biochemistry, and behavior · 2015Article
- Behavioral and neuronal recording of the nucleus accumbens in adolescent rats following acute and repetitive exposure to methylphenidate.Journal of neurophysiology · 2015Article
- Nucleus accumbens neuronal activity correlates to the animal's behavioral response to acute and chronic methylphenidate.Physiology & behavior · 2014Article
- Acute administration of methylphenidate alters the prefrontal cortex neuronal activity in a dose-response characteristic.Journal of experimental pharmacology · 2014Article
- Acute and chronic dose-response effect of methylphenidate on ventral tegmental area neurons correlated with animal behavior.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Adult female rats' altered diurnal locomotor activity pattern following chronic methylphenidate treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Dorsal raphe neuronal activities are modulated by methylphenidate.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Performance on a strategy set shifting task during adolescence in a genetic model of attention deficit/hyperactivity disorder: methylphenidate vs. atomoxetine treatments.Behavioural brain research · 2013Article
- Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- The use of medication against attention deficit/hyperactivity disorder in Denmark: a drug use study from a patient perspective.European journal of clinical pharmacology · 2013Article
- Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons.Neuropharmacology · 2013Article
- Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat.European journal of pharmacology · 2012Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Today's students around the world are striking deals to buy and sell the drug methylphenidate (MPD) for cognitive enhancement. Our knowledge on the effects of MPD on the brain is very limited. The present study was designed to investigate the acute and chronic effect of MPD on the prefrontal cortex (PFC) neurons. On experimental day 1 (ED1) recordings were obtained following saline injections and after 2.5 mg/kg MPD. On ED2 through ED6, daily single 2.5 mg/kg MPD was given followed by 3 washout days (ED7 to 9). On ED10, neuronal recordings were resumed from the same animal after saline and MPD injection similar to that obtained at ED1. Ninety PFC units were recorded, all responded to the initial MPD injection, 66 units (73%) increased their activity at ED10. Recordings were resumed for the 66 units that increased their firing rate at ED1, and following MPD injection 54 units (82%) exhibited significant increases in their baseline firing rates compared to ED1 baseline. When these 54 units were rechallenged (chronic effect) with MPD, 39/54 (72%) exhibited reduction in their firing rate which can be interpreted as tolerance. From the 24 (27%) units that responded to MPD at ED1 by decreasing their activity, 14 units (58%) exhibited a decrease in their baseline firing rates at ED10 compared to ED1 baseline. However, following MPD rechallenge of these 14 units, 11 units (79%) exhibited an increase in their firing rate which is interpreted as sensitization. In conclusion, all PFC units modified their neural baseline activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.