ArticleThe Journal of pediatrics2012
Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy.
Article in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Continuous Glucose Monitoring on Cerebral Oxygenation in Preterm Infants (the Babyglucolight Trial)
Management of Intrapartum Glycemia in Gestational Diabetic Mothers: A Randomized Controlled Trial
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Neuroprotective effect of Src kinase in hypoxia-ischemia: A systematic review.Frontiers in neuroscience · 2022Pooled it
- Trial
- Continuous Glucose Monitoring and Hypoglycaemia Risk During Paediatric DKA Treatment in the PICU: A Retrospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Early-life programming of hypothalamic circuits by maternal obesity: implications for neuroendocrine disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Effect of FSL-CGM on Maternal and Neonatal Outcomes in GDM: A Propensity Score Matching Study in Hangzhou, China.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- A comparison of short- and long-term prognoses between cases with and without antenatal corticosteroid administration in late preterm delivery: a nationwide population-based study.BMC pregnancy and childbirth · 2025Observational
- Blood glucose and β-hydroxybutyrate predict significant brain injury after hypoxia-ischemia in neonatal mice.Pediatric research · 2025Article
- Improving blood glucose in late preterm and small for gestational age infants: the use of dextrose 40% gel.Frontiers in pediatrics · 2025Article
- Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes.Pediatric research · 2024Review
- Late preterm antenatal steroid use and infant outcomes in a single center.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Incidence of encephalopathy and comorbidity in infants with perinatal asphyxia: a comparative prospective cohort study.Frontiers in pediatrics · 2024Article
- Brain magnetic resonance imaging review suggests unrecognised hypoglycaemia in childhood.Frontiers in endocrinology · 2024Review
- Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes.Pediatric endocrinology, diabetes, and metabolism · 2024Article
- Late Preterm Antenatal Steroid Use and Infant Outcomes in a Single Center.Research square · 2023Article
- Early neonatal hypoglycemia in exclusively breastfed babies in a developing country - India.Journal of family medicine and primary care · 2023Article
- Article
- Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy.Pediatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the contribution of hypoglycemia in the first 24 hours after birth to brain injury in term newborns at risk for neonatal encephalopathy. STUDY
designA prospective cohort of 94 term neonates born between 1994 and 2010 with early postnatal brain magnetic resonance imaging studies were analyzed for regions of brain injury. Neurodevelopmental outcome was assessed at 1 year of age.
resultsHypoglycemia (glucose <46 mg/dL) in the first 24 hours after birth was detected in 16% of the cohort. Adjusting for potential confounders of early perinatal distress and need for resuscitation, neonatal hypoglycemia was associated with a 3.72-fold increased odds of corticospinal tract injury (P=.047). Hypoglycemia was also associated with 4.82-fold increased odds of 1-point worsened neuromotor score (P=.038) and a 15-point lower cognitive and language score on the Bayley Scales of Infant Development (P=.015).
conclusionNeonatal hypoglycemia is associated with additional risks in the setting of neonatal encephalopathy with increased corticospinal tract injury and adverse motor and cognitive outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.