ArticleDrug and alcohol dependence2012
Escalation of methamphetamine self-administration in adolescent and adult rats.
Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Cocaine self-administration in adult female and male rhesus monkeys: longitudinal comparison with adolescent behavior and role of early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats.Developmental neuroscience · 2025Article
- The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Age- and Sex-Dependent Nicotine Pretreatment Effects on the Enhancement of Methamphetamine Self-administration in Sprague-Dawley Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- The effects of alcohol drinking on subsequent methamphetamine self-administration and relapse in adolescent female rats.Behavioural brain research · 2022Article
- Peri-adolescent exposure to (meth)amphetamine in animal models.International review of neurobiology · 2022Review
- Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior.Drug and alcohol dependence · 2021Article
- Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice.Frontiers in pharmacology · 2021Article
- AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.Pharmacology, biochemistry, and behavior · 2020Review
- Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats.Behavioural brain research · 2020Article
- Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- A review of nonhuman primate models of early life stress and adolescent drug abuse.Neurobiology of stress · 2018Review
- Age and sex differences in behavioral flexibility, sensitivity to reward value, and risky decision-making.Behavioral neuroscience · 2018Article
- Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes.Psychopharmacology · 2018Article
- Modeling the development of drug addiction in male and female animals.Pharmacology, biochemistry, and behavior · 2018Review
- Tobacco's minor alkaloids: Effects on place conditioning and nucleus accumbens dopamine release in adult and adolescent rats.European journal of pharmacology · 2017Article
- Escalation of intravenous self-administration of methylone and mephedrone under extended access conditions.Addiction biology · 2017Article
- Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice.Behavioural brain research · 2017Article
- Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances via Preclinical Models of Drug Self-administration.Current topics in behavioral neurosciences · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMethamphetamine (METH) use has increased substantially in the last 10 years and poses a serious health concern, especially for young populations. Drug abuse primarily begins during adolescence, when uninhibited and excessive and drug intake is a common occurrence; thus, understanding the developmental patterns of addiction during this critical period is an essential step in its prevention. In the present study, the effect of age on the vulnerability to METH abuse was examined using a rat model of bingeing (i.e., escalation).
methodsAdolescent and adult rats were compared during short (ShA, 2-h) and long-access (LgA, 6-h) to METH self-administration. On postnatal (PN) days 23 (adolescents) and 90 (adults), rats were implanted with i.v. catheters and trained to lever press for infusions of METH (0.05mg/kg) during 2-h sessions. Once the rats reached a steady rate of METH self-administration, they were divided into ShA or LgA groups and allowed to self-administer METH for 15 additional days.
resultsResults indicated that adolescent rats earned significantly more infusions than adults under the LgA condition, but the age groups did not differ during ShA. Adolescents, but not adults, also significantly increased (i.e., escalated) METH self-administration across the 15 days of testing under the LgA condition. Further analysis indicated excessive responding during infusions in the LgA METH-exposed adolescents compared to the other groups, suggesting elevated impulsivity or motivation for drug.
conclusionThese results demonstrate that adolescents are more vulnerable to the escalation of METH than adults during LgA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.