Evidence map›Paper›PMID 22305766›Full record

ArticleLancet (London, England)2012

Depression in adolescence.

Anita Thapar, Stephan Collishaw, Daniel S Pine, Ajay K Thapar

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 997 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
997citing papers in PubMed, 14 pooled it
77.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05997173 unknown statusnot on this mapstarted 2020, after this paper: background citation

The Regulatory Role of Immune Response in Oral Lichen Planus With Mental Disorders

TypeobservationalSponsorPeking University Third HospitalRan2020 to 2025Enrolled90ConditionsOral Lichen PlanusArmsControl, Non erosive OLP, Erosive OLP
NCT07163013 narecruitingnot on this mapstarted 2025, after this paper: background citation

Digital Cognitive Behavioral Therapy for Chinese Adolescents With Depressive Symptoms（CADS-D ): A Randomized Clinical Trial

TypeinterventionalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2025 to 2026Enrolled200ConditionsDepressive SymptomArmsDigital cognitive behavioral therapy(DCBT), Regular mental health curriculum
3 · Its place in the literature

Who cites it

997 citing papers in PubMed, 14 syntheses or guidelines pooled it, 2,255 citations in OpenAlex.

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  2. Delayed school start times to improve sleep duration and mitigate depression in adolescents: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
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937 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anita ThaparChild & Adolescent Psychiatry Section, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Wales, UK. thapar@Cardiff .ac.uk
Stephan Collishaw
Daniel S Pine
Ajay K Thapar
Cardiff University · GBRiverside · GB

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Fmri Studies Of Emotional DevelopmentZIAMH002780 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2011
$2.7M
Intramural NIH HHS ZIA MH002780Intramural NIH HHS ZIA MH002781Intramural NIH HHS ZIA MH002782Medical Research Council G9810900
6 · The paper itself

Abstract

Unipolar depressive disorder in adolescence is common worldwide but often unrecognised. The incidence, notably in girls, rises sharply after puberty and, by the end of adolescence, the 1 year prevalence rate exceeds 4%. The burden is highest in low-income and middle-income countries. Depression is associated with substantial present and future morbidity, and heightens suicide risk. The strongest risk factors for depression in adolescents are a family history of depression and exposure to psychosocial stress. Inherited risks, developmental factors, sex hormones, and psychosocial adversity interact to increase risk through hormonal factors and associated perturbed neural pathways. Although many similarities between depression in adolescence and depression in adulthood exist, in adolescents the use of antidepressants is of concern and opinions about clinical management are divided. Effective treatments are available, but choices are dependent on depression severity and available resources. Prevention strategies targeted at high-risk groups are promising.

Indexed as

AdolescentDepressive DisorderDiagnosis, DifferentialFemaleHumansIncidenceMalePrevalenceRisk FactorsUnited KingdomUnited StatesYoung Adult

Identifiers

PMID22305766
PMCPMC3488279
OpenAlexW2130901187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.