ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2012
Trajectories of kidney function decline in the 2 years before initiation of long-term dialysis.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
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Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Regression methods for investigating risk factors of chronic kidney disease outcomes: the state of the art.BMC nephrology · 2014Pooled it
- Exploring mHealth potential to improve kidney function: secondary analysis of a randomized trial of diabetes self-care in diverse adults.BMC nephrology · 2022Trial
- Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Trial
- Length of Follow-Up Time Needed for Stable eGFR Slope Estimation in Glomerular Disease.Kidney360 · 2026Article
- Trajectories of kidney function over 10 years in patients with chronic kidney disease: a 10 year follow-up of FROM-J study.Clinical and experimental nephrology · 2026Article
- Twelve-Month Estimated Glomerular Filtration Rate Trajectory at the Time of Kidney Replacement Therapy Counseling Predicts Dialysis Initiation Within One Year.Journal of clinical medicine · 2025Article
- Acute Kidney Injury and Subsequent Kidney Failure With Replacement Therapy Incidence in Older Adults With Advanced CKD: A Cohort Study of US Veterans.Kidney medicine · 2024Article
- Trajectories of kidney function and risk of mortality.International journal of epidemiology · 2023Article
- Associations between abrupt transition, dialysis-requiring AKI, and early mortality in ESKD among U.S. veterans.BMC nephrology · 2023Article
- Incidence of hospital-acquired acute kidney injury and trajectories of glomerular filtration rate in older adults.BMC nephrology · 2023Article
- Costs Associated With Progression of Mildly Reduced Kidney Function Among Medicare Advantage Enrollees.Kidney medicine · 2023Article
- Article
- Machine Learning Case Study: Patterns of Kidney Function Decline and Their Association With Clinical Outcomes Within 90 Days After the Initiation of Renal Dialysis.Advances in kidney disease and health · 2023Review
- Kidney failure, CKD progression and mortality after nephrectomy.International urology and nephrology · 2022Article
- Impact of Kidney Failure Risk Prediction Clinical Decision Support on Monitoring and Referral in Primary Care Management of CKD: A Randomized Pragmatic Clinical Trial.Kidney medicine · 2022Article
- Advance Care Planning Documentation and Intensity of Care at the End of Life for Adults With Congestive Heart Failure, Chronic Kidney Disease, and Both Illnesses.Journal of pain and symptom management · 2022Article
- Comparison of a Kidney Replacement Therapy Risk Score Developed in Kaiser Permanente Northwest vs Estimated Glomerular Filtration Rate in Advanced Chronic Kidney Disease Using Decision Curve Analysis.The Permanente journal · 2021Article
- Different kidney function trajectory patterns before dialysis in elderly patients: clinical implications and outcomes.Renal failure · 2021Article
- Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond.Journal of clinical medicine · 2021Review
45 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
backgroundLittle is known about patterns of kidney function decline leading up to the initiation of long-term dialysis. STUDY
designRetrospective cohort study. SETTING &
participants5,606 Veterans Affairs patients who initiated long-term dialysis in 2001-2003. PREDICTOR: Trajectory of estimated glomerular filtration rate (eGFR) during the 2-year period before initiation of long-term dialysis. OUTCOMES & MEASUREMENTS: Patient characteristics and care practices before and at the time of dialysis initiation and survival after initiation.
resultsWe identified 4 distinct trajectories of eGFR during the 2-year period before dialysis initiation: 62.8% of patients had persistently low level of eGFR < 30 mL/min/1.73 m2 (mean eGFR slope, 7.7 ± 4.7 [SD] mL/min/1.73 m2 per year), 24.6% had progressive loss of eGFR from levels of approximately 30-59 ml/min/1.73 m2 (mean eGFR slope, 16.3 ± 7.6 mL/min/1.73 m2 per year), 9.5% had accelerated loss of eGFR from levels > 60 mL/min/1.73 m2 (mean eGFR slope, 32.3 ± 13.4 mL/min/1.73 m2 per year), and 3.1% experienced catastrophic loss of eGFR from levels > 60 mL/min/1.73 m2 within 6 months or less. Patients with steeper eGFR trajectories were more likely to have been hospitalized and have an inpatient diagnosis of acute kidney injury. They were less likely to have received recommended predialysis care and had a higher risk of death in the first year after dialysis initiation.
conclusionsThere is substantial heterogeneity in patterns of kidney function loss leading up to the initiation of long-term dialysis perhaps calling for a more flexible approach toward preparing for end-stage renal disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.